Type I Interferon Modulates the Battle of Host Immune System Against Viruses
DC Field | Value | Language |
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dc.contributor.author | Seo, Young-Jin | - |
dc.contributor.author | Hahm, Bumsuk | - |
dc.date.accessioned | 2022-05-18T01:40:07Z | - |
dc.date.available | 2022-05-18T01:40:07Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.issn | 0065-2164 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57769 | - |
dc.description.abstract | Type I interferon (IFN), as its name implies, 'interferes' with virus replication by activating numerous genes. Further, virus-induced type I IFN regulates the magnitude and functions of cells directing the host immune system. Importantly, recent exploration into how type I IFN operates following virus infection has advanced our understanding of its role with respect to modulation of host innate and adaptive immune responses. Such activities include the activation of antigen-presenting dendritic cells and the localization, expansion or differentiation of virus-specific T lymphocytes and antibody-producing B lymphocytes. However, type I IFN not only benefits the host but can also induce unnecessary or extremely pathogenic immune responses. This review focuses on such interactions and the manner in which type I IFN induces dynamic changes in the host immune network, particularly adaptive immune responses to viral invasion. Manipulating the type I IFN-mediated host immune response during virus infections could provide new immunotherapeutic interventions to remedy viral diseases and implement more effective and sustainable type I IFN therapy. | - |
dc.format.extent | 19 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER ACADEMIC PRESS INC | - |
dc.title | Type I Interferon Modulates the Battle of Host Immune System Against Viruses | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/S0065-2164(10)73004-5 | - |
dc.identifier.bibliographicCitation | ADVANCES IN APPLIED MICROBIOLOGY, VOL 73, v.73, pp 83 - 101 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000282064800004 | - |
dc.identifier.scopusid | 2-s2.0-77956113383 | - |
dc.citation.endPage | 101 | - |
dc.citation.startPage | 83 | - |
dc.citation.title | ADVANCES IN APPLIED MICROBIOLOGY, VOL 73 | - |
dc.citation.volume | 73 | - |
dc.type.docType | Review; Book Chapter | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | PLASMACYTOID DENDRITIC CELLS | - |
dc.subject.keywordPlus | CD8 T-CELLS | - |
dc.subject.keywordPlus | DOUBLE-STRANDED-RNA | - |
dc.subject.keywordPlus | IFN-ALPHA | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | VIRAL-INFECTIONS | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | LISTERIA-MONOCYTOGENES | - |
dc.subject.keywordPlus | CLONAL EXPANSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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