Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiation
DC Field | Value | Language |
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dc.contributor.author | Cho, Y.-W. | - |
dc.contributor.author | Jee, S. | - |
dc.contributor.author | Suhito, I.R. | - |
dc.contributor.author | Lee, J.-H. | - |
dc.contributor.author | Park, C.G. | - |
dc.contributor.author | Choi, K.M. | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.date.accessioned | 2022-05-19T10:40:17Z | - |
dc.date.available | 2022-05-19T10:40:17Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57810 | - |
dc.description.abstract | Stable and continuous supply of essential biomolecules is critical to mimic in vivo microenvironments wherein spontaneous generation of various cell types occurs. Here, we report a new platform that enables highly efficient neuronal cell generation of neural stem cells using single metal-organic framework (MOF) nanoparticle–embedded nanopit arrays (SMENA). By optimizing the physical parameters of homogeneous periodic nanopatterns, each nanopit can confine single nMOFs (UiO-67) that are specifically designed for long-term storage and release of retinoic acid (RA). The SMENA platform successfully inhibited physical interaction with cells, which contributed to remarkable stability of the nMOF (RA⊂UiO-67) structure without inducing nanoparticle-mediated toxicity issues. Owing to the continuous and long-term supply of RA, the neural stem cells showed enhanced mRNA expressions of various neurogenesis-related activities. The developed SMENA platform can be applied to other stem cell sources and differentiation lineages and is therefore useful for various stem cell–based regenerative therapies. Copyright © 2022 The Authors, some rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.title | Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.abj7736 | - |
dc.identifier.bibliographicCitation | Science Advances, v.8, no.16 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000786214100009 | - |
dc.identifier.scopusid | 2-s2.0-85128598831 | - |
dc.citation.number | 16 | - |
dc.citation.title | Science Advances | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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