Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Shifting role of cytoreductive nephrectomy according to type of systemic therapy: A nationwide cohort study

Full metadata record
DC Field Value Language
dc.contributor.authorChoi, Se Young-
dc.contributor.authorHa, Moon Soo-
dc.contributor.authorLee, Jeong Woo-
dc.contributor.authorKim, Jae Hwan-
dc.contributor.authorKim, Jung Hoon-
dc.contributor.authorChi, Byung Hoon-
dc.contributor.authorKim, Jin Wook-
dc.contributor.authorChang, In Ho-
dc.contributor.authorKim, Tae-Hyoung-
dc.contributor.authorMyung, Soon Chul-
dc.date.accessioned2022-05-19T11:40:11Z-
dc.date.available2022-05-19T11:40:11Z-
dc.date.issued2023-01-
dc.identifier.issn1015-9584-
dc.identifier.issn0219-3108-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/57866-
dc.description.abstractPurpose: The best protocol of cytoreductive nephrectomy (CN) and systemic therapy (ST) in the treatment of metastatic renal cell carcinoma (mRCC) remains unclear. We sought to evaluate overall survival (OS) in patients with mRCC treated with ST with or without CN. Methods: We collected data from the National Health Insurance Service database. We excluded 2 years of washout period, 2 years of follow-up period, other cancer diagnoses within 2 years, and ≥4 months interval between ST and CN. The patients were divided into two groups according to whether CN was performed. Kaplan–Meier, propensity score matching, Cox regression model, and incremental survival analyses were conducted. Additionally, we performed subgroup analysis according to whether cytokine therapy or targeted therapy was used as first-line ST. Results: Of 6478 patients, 1707 (26.4%) underwent CN. The CN group showed significantly better OS than the no CN group (p < 0.001). In the cytokine therapy subgroup, patients who underwent CN had significantly higher OS than those who did not (p < 0.001). In the targeted therapy subgroup, no significant difference was found (p = 0.867). In multivariate analysis, CN was associated with better OS in the total cohort (hazard ratio 0.819, p < 0.001). The incremental OS benefit of CN ranged from +0.98 in patients who survived for <24 months to +2.13 in those who survived during all periods. Conclusion: About a quarter patients with mRCC from a nationwide database were treated with CN and ST. CN was beneficial in specific patients with mRCC. Patient selection is crucial for obtaining the benefits of CN. © 2022 Asian Surgical Association and Taiwan Robotic Surgery Association-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherElsevier (Singapore) Pte Ltd-
dc.titleShifting role of cytoreductive nephrectomy according to type of systemic therapy: A nationwide cohort study-
dc.typeArticle-
dc.identifier.doi10.1016/j.asjsur.2022.04.008-
dc.identifier.bibliographicCitationAsian Journal of Surgery, v.46, no.1, pp 328 - 336-
dc.description.isOpenAccessY-
dc.identifier.wosid000908065500010-
dc.identifier.scopusid2-s2.0-85128548985-
dc.citation.endPage336-
dc.citation.number1-
dc.citation.startPage328-
dc.citation.titleAsian Journal of Surgery-
dc.citation.volume46-
dc.type.docTypeArticle; Early Access-
dc.publisher.location싱가폴-
dc.subject.keywordAuthorCytokine therapy-
dc.subject.keywordAuthorCytoreductive nephrectomy-
dc.subject.keywordAuthorMetastatic renal cell carcinoma-
dc.subject.keywordAuthorOverall survival-
dc.subject.keywordAuthorTarget therapy-
dc.subject.keywordPlusRENAL-CELL CARCINOMA-
dc.subject.keywordPlusMANAGEMENT-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusERA-
dc.relation.journalResearchAreaSurgery-
dc.relation.journalWebOfScienceCategorySurgery-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
Appears in
Collections
ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Tae-Hyoung photo

Kim, Tae-Hyoung
의과대학 (의학부(임상-서울))
Read more

Altmetrics

Total Views & Downloads

BROWSE