Histone Acetyltransferase-dependent Chromatin Remodeling and Vascular Clock
DC Field | Value | Language |
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dc.contributor.author | Curtis, Anne M. | - |
dc.contributor.author | Seo, Sang-beom | - |
dc.contributor.author | Westgate, Elizabeth J. | - |
dc.contributor.author | Rudic, Radu Daniel | - |
dc.contributor.author | Smyth, Emer M. | - |
dc.contributor.author | Chakravarti, Debabrata | - |
dc.contributor.author | FitzGerald, Garret A. | - |
dc.contributor.author | McNamara, Peter | - |
dc.date.accessioned | 2022-05-30T06:40:16Z | - |
dc.date.available | 2022-05-30T06:40:16Z | - |
dc.date.issued | 2004-02 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58159 | - |
dc.description.abstract | Rhythmic gene expression is central to the circadian control of physiology in mammals. Transcriptional activation of Per and Cry genes by heterodimeric bHLH-PAS proteins is a key event in the feedback loop that drives rhythmicity; however, the mechanism is not clearly understood. Here we show the transcriptional coactivators and histone acetyltransferases, p300/CBP, PCAF, and ACTR associate with the bHLH-PAS proteins, CLOCK and NPAS2, to regulate positively clock gene expression. Furthermore, Cry2 mediated repression of NPAS2:BMAL1 is overcome by overexpression of p300 in transactivation assays. Accordingly, p300 exhibits a circadian time-dependent association with NPAS2 in the vasculature, which precedes peak expression of target genes. In addition, a rhythm in core histone H3 acetylation on the mPer1 promoter in vivo correlates with the cyclical expression of their mRNAs. Temporal coactivator recruitment and HAT-dependent chromatin remodeling on the promoter of clock controlled genes in the vasculature permits the mammalian clock to orchestrate circadian gene expression. | - |
dc.format.extent | 7 | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.title | Histone Acetyltransferase-dependent Chromatin Remodeling and Vascular Clock | - |
dc.title.alternative | 히스톤 아세틸화에 의한 크로마틴 재구성과 순환기의 생물학적시계 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1074/jbc.M311973200 | - |
dc.identifier.bibliographicCitation | Journal of Biological Chemistry, v.279 , no.8, pp 7091 - 7097 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-1342282943 | - |
dc.citation.endPage | 7097 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 7091 | - |
dc.citation.title | Journal of Biological Chemistry | - |
dc.citation.volume | 279 | - |
dc.publisher.location | 미국 | - |
dc.description.journalRegisteredClass | scopus | - |
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