GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actinomadura sp. RB99
DC Field | Value | Language |
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dc.contributor.author | Lee, Seoung Rak | - |
dc.contributor.author | Schalk, Felix | - |
dc.contributor.author | Schwitalla, Jan W. | - |
dc.contributor.author | Guo, Huijuan | - |
dc.contributor.author | Yu, Jae Sik | - |
dc.contributor.author | Song, Moonyong | - |
dc.contributor.author | Jung, Won Hee | - |
dc.contributor.author | Beer, Z. Wilhelm | - |
dc.contributor.author | Beemelmanns, Christine | - |
dc.contributor.author | Kim, Ki Hyun | - |
dc.date.accessioned | 2022-06-08T00:40:17Z | - |
dc.date.available | 2022-06-08T00:40:17Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.issn | 1521-3765 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58235 | - |
dc.description.abstract | In this study, we analyzed if Actinomadura sp. RB99 produces siderophores that that could be responsible for the antimicrobial activity observed in co-cultivation studies. Dereplication of high-resolution tandem mass spectrometry (HRMS/MS) and global natural product social molecular networking platform (GNPS) analysis of fungus-bacterium co-cultures resulted in the identification of five madurastatin derivatives (A1, A2, E1, F, and G1), of which were four new derivatives. Chemical structures were unambiguously confirmed by HR-ESI-MS, 1D and 2D NMR experiments, as well as MS/MS data and their absolute structures were elucidated based on Marfey's analysis, DP4+ probability calculation and total synthesis. Structure analysis revealed that madurastatin E1 (2) contained a rare 4-imidazolidinone cyclic moiety and madurastatin A1 (5) was characterized as a Ga3+-complex. The function of madurastatins as siderophores was evaluated using the fungal pathogen Cryptococcus neoformans as model organism. Based on homology models, we identified the putative NRPS-based gene cluster region of the siderophores in Actinomadura sp. RB99. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | GNPS-Guided Discovery of Madurastatin Siderophores from the Termite-Associated Actinomadura sp. RB99 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/chem.202200612 | - |
dc.identifier.bibliographicCitation | CHEMISTRY-A EUROPEAN JOURNAL, v.28, no.36 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000797646800001 | - |
dc.identifier.scopusid | 2-s2.0-85130424933 | - |
dc.citation.number | 36 | - |
dc.citation.title | CHEMISTRY-A EUROPEAN JOURNAL | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 독일 | - |
dc.subject.keywordAuthor | metabolomics | - |
dc.subject.keywordAuthor | microbial communication | - |
dc.subject.keywordAuthor | natural products | - |
dc.subject.keywordAuthor | siderophores | - |
dc.subject.keywordPlus | IRON ACQUISITION | - |
dc.subject.keywordPlus | NATURAL-PRODUCTS | - |
dc.subject.keywordPlus | MBJ-0034 | - |
dc.subject.keywordPlus | C1 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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