Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, So-Yeon | - |
dc.contributor.author | Kim, Da-Seul | - |
dc.contributor.author | Kim, Hyun-Mun | - |
dc.contributor.author | Lee, Jun-Kyu | - |
dc.contributor.author | Hwang, Dong-Youn | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | You, Seungkwon | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.accessioned | 2022-08-16T05:40:07Z | - |
dc.date.available | 2022-08-16T05:40:07Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58517 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) have been adopted in various preclinical and clinical studies because of their multipotency and low immunogenicity. However, numerous obstacles relating to safety issues remain. Therefore, MSC-derived extracellular vesicles (EVs) have been recently employed. EVs are nano-sized endoplasmic reticulum particles generated and released in cells that have similar biological functions to their origin cells. EVs act as cargo for bioactive molecules such as proteins and genetic materials and facilitate tissue regeneration. EVs obtained from adipose-derived MSC (ADMSC) also have neuroprotective and neurogenesis effects. On the basis of the versatile effects of EVs, we aimed to enhance the neural differentiation ability of ADMSC-derived EVs by elucidating the neurogenic-differentiation process. ADMSC-derived EVs isolated from neurogenesis conditioned media (differentiated EVs, dEVs) increased neurogenic ability by altering innate microRNA expression and cytokine composition. Consequently, dEVs promoted neuronal differentiation of neural progenitor cells in vitro, suggesting that dEVs are a prospective candidate for EV-based neurological disorder regeneration therapy. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Human Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Neural Differentiation of Neural Progenitor Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/ijms23137047 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.13 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000823923000001 | - |
dc.identifier.scopusid | 2-s2.0-85132745167 | - |
dc.citation.number | 13 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | extracellular vesicle (EV) | - |
dc.subject.keywordAuthor | mesenchymal stem cell | - |
dc.subject.keywordAuthor | neural progenitor cell | - |
dc.subject.keywordAuthor | neurogenesis | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INJURY | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.