Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique
DC Field | Value | Language |
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dc.contributor.author | Han, J.-H. | - |
dc.contributor.author | Lee, Y.Y. | - |
dc.contributor.author | Shin, H.E. | - |
dc.contributor.author | Han, J. | - |
dc.contributor.author | Kang, J.M. | - |
dc.contributor.author | James, Wang C.-P. | - |
dc.contributor.author | Park, J.-H. | - |
dc.contributor.author | Kim, S.-N. | - |
dc.contributor.author | Yoon, J.-H. | - |
dc.contributor.author | Kwon, H.-K. | - |
dc.contributor.author | Park, D.-H. | - |
dc.contributor.author | Park, T.-E. | - |
dc.contributor.author | Choy, Y.B. | - |
dc.contributor.author | Kim, D.-H. | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Min, Jun Hong | - |
dc.contributor.author | Kim, I.-H. | - |
dc.contributor.author | Park, C.G. | - |
dc.contributor.author | Han, D.K. | - |
dc.contributor.author | Park, W. | - |
dc.date.accessioned | 2022-11-04T07:40:14Z | - |
dc.date.available | 2022-11-04T07:40:14Z | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/58945 | - |
dc.description.abstract | Cancer immunotherapy is a next-generation treatment strategy; however, its side effects limit its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) prepared with an iron oxide/gold core and a cationic polymer shell via multilayer synthesis with CpG oligodeoxynucleotide (CpG-ODN) electrostatically complexed on its surface, and irreversible electroporation (IRE) technique was developed for effective image-guided in situ cancer vaccination. The M-NA can be retained long-term in the dense tumoral extracellular matrix after intratumoral injection and internalized by antigen-presenting cells (APCs). The IRE can induce immunogenic cell death. Indeed, in a mouse tumor model, the M-NA showed longer tumor retention time than free CpG-ODN. Compared with other treatments, the combined treatment significantly inhibited tumor growth with 100% survival rate for ∼60 days. The therapy induced the activation of cytotoxic lymphocytes and the maturation of APCs in vivo. This treatment could be effective in image-guided local cancer immunotherapy. © 2022 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121762 | - |
dc.identifier.bibliographicCitation | Biomaterials, v.289 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000855945200002 | - |
dc.identifier.scopusid | 2-s2.0-85137033815 | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 289 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | Image-guided cancer therapy | - |
dc.subject.keywordAuthor | Irreversible electroporation | - |
dc.subject.keywordAuthor | Multi-functional nano-adjuvant | - |
dc.subject.keywordPlus | IMMUNOGENIC CELL-DEATH | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | CPG | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | IPILIMUMAB | - |
dc.subject.keywordPlus | NIVOLUMAB | - |
dc.subject.keywordPlus | ABLATION | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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