Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool
DC Field | Value | Language |
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dc.contributor.author | Kim, Ji-Won | - |
dc.contributor.author | Park, Sunghoon | - |
dc.contributor.author | Jung, Ju-Yang | - |
dc.contributor.author | Kim, Hyoun-Ah | - |
dc.contributor.author | Kwon, Seong-Ryul | - |
dc.contributor.author | Choi, Sang Tae | - |
dc.contributor.author | Kim, Sung-Soo | - |
dc.contributor.author | Kim, Sang-Hyeon | - |
dc.contributor.author | Suh, Chang-Hee | - |
dc.date.accessioned | 2022-12-02T09:40:08Z | - |
dc.date.available | 2022-12-02T09:40:08Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59478 | - |
dc.description.abstract | Background: We investigated the prevalence of and the factors associated with a high risk of osteoporotic fractures in Korean patients with ankylosing spondylitis (AS). Methods: This was a multicenter, retrospective study including 219 AS patients from five university hospitals; the control group was selected by matching age and sex with those of the AS patients. The fracture risk was evaluated based on bone mineral density (BMD) measured by dual-energy X-ray absorptiometry and the fracture risk assessment tool (FRAX) with/without BMD. Results: The mean age of the patients was 47.6 years, and 144 (65.8%) patients were men. According to the WHO criteria and FRAX with/without BMD, the candidates for pharmacological treatment were 44 (20.1%), 20 (13.2%), and 23 (15.1%) patients, respectively, significantly more than those in the healthy control group. Among them, the proportion of patients receiving osteoporosis treatment was 39.1-75%. In logistic regression analysis, menopause was an independent factor for the high risk of fracture according to the WHO criteria and FRAX with/without BMD. C-reactive protein level (odds ratio (OR) 3.8 and OR 6) and glucocorticoid use (OR 1.5 and OR 1.7) were associated with a high risk of osteoporotic fracture based on FRAX without BMD and osteoporosis diagnosed according to the WHO criteria. Conclusions: Our study suggests that both FRAX and WHO criteria may be complementary for treatment decisions to reduce osteoporotic fractures in patients with AS. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Prevalence and Factors of Osteoporosis and High Risk of Osteoporotic Fracture in Patients with Ankylosing Spondylitis: A Multicenter Comparative Study of Bone Mineral Density and the Fracture Risk Assessment Tool | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/jcm11102830 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.11, no.10 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000801560500001 | - |
dc.identifier.scopusid | 2-s2.0-85130162533 | - |
dc.citation.number | 10 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | ankylosing spondylitis | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | osteoporotic fracture | - |
dc.subject.keywordAuthor | bone mineral density | - |
dc.subject.keywordAuthor | fracture risk assessment tool | - |
dc.subject.keywordPlus | AXIAL SPONDYLOARTHRITIS | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | HLA-B27 | - |
dc.subject.keywordPlus | HEALTH | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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