Post-marketing surveillance study on influenza vaccine in South Korea using a nationwide spontaneous reporting database with multiple data mining methods
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyesung | - |
dc.contributor.author | Hong, Bin | - |
dc.contributor.author | Kim, Sanghee | - |
dc.contributor.author | Kim, Ju Hwan | - |
dc.contributor.author | Choi, Nam-Kyong | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.contributor.author | Shin, Ju-Young | - |
dc.date.accessioned | 2022-12-16T05:40:48Z | - |
dc.date.available | 2022-12-16T05:40:48Z | - |
dc.date.issued | 2022-11 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59673 | - |
dc.description.abstract | Safety profiles of the influenza vaccine and its subtypes are still limited. We aimed to address this knowledge gap using multiple data mining methods and calculated performance measurements to evaluate the precision of different detection methods. We conducted a post-marketing surveillance study between 2005 and 2019 using the Korea Adverse Event Reporting System database. Three data mining methods were applied: (a) proportional reporting ratio, (b) information component, and (c) tree-based scan statistics. We evaluated the performance of each method in comparison with the known adverse events (AEs) described in the labeling information. Compared to other vaccines, we identified 36 safety signals for the influenza vaccine, and 7 safety signals were unlabeled. In subtype-stratified analyses, application site disorders were reported more frequently with quadrivalent and cell-based vaccines, while a wide range of AEs were noted for trivalent and egg-based vaccines. Tree-based scan statistics showed well-balanced performance. Among the detected signals of influenza vaccines, narcolepsy requires special attention. A wider range of AEs were detected as signals for trivalent and egg-based vaccines. Although tree-based scan statistics showed balanced performance, complementary use of other techniques would be beneficial when large noise due to false positives is expected. © 2022, The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Research | - |
dc.title | Post-marketing surveillance study on influenza vaccine in South Korea using a nationwide spontaneous reporting database with multiple data mining methods | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-022-21986-8 | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.12, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000888059100005 | - |
dc.identifier.scopusid | 2-s2.0-85142639946 | - |
dc.citation.number | 1 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | EVENTS FOLLOWING IMMUNIZATION | - |
dc.subject.keywordPlus | GUILLAIN-BARRE-SYNDROME | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | BELLS-PALSY | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | SIGNAL | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.