Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, J.Y. | - |
dc.contributor.author | Lim, Y.G. | - |
dc.contributor.author | Song, Y.J. | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2023-01-19T05:41:08Z | - |
dc.date.available | 2023-01-19T05:41:08Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 0141-8130 | - |
dc.identifier.issn | 1879-0003 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/59905 | - |
dc.description.abstract | Tumor microenvironment (TME)-responsive manganese dioxide (MnO2) nanoparticles as a good T1 contrast agent could reduce unwanted toxicity and improve the accuracy of cancer detection. Despite these distinct advantages of MnO2-based nanoparticles, their synthesis involves multi-step processes with relatively long synthesis times. In this study, we synthesized histidine-modified hyaluronic acid (HA-His), and the prepared HA-His conjugates quickly reduce permanganate to MnO2, leading to facile production of HA-His/MnO2 nanoparticles with good water-dispersibility and stability under biological conditions. The synthesized HA-His/MnO2 nanoparticles readily responded to the TME (low pH, high H2O2, and high glutathione), and they were internalized into SCC7 cells with high CD44 expression. Moreover, the systemically administered HA-His/MnO2 nanoparticles with biocompatibility were specifically accumulated in tumor tissues, thereby efficiently enhancing T1 contrast in MRI. Therefore, the HA-His/MnO2 nanoparticles synthesized herein can be used as a promising T1 contrast agent for tumor MR imaging. © 2022 Elsevier B.V. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Tumor microenvironment-responsive histidine modified-hyaluronic acid-based MnO2 as in vivo MRI contrast agent | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijbiomac.2022.12.033 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Macromolecules, v.226, pp 121 - 131 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000975183200001 | - |
dc.identifier.scopusid | 2-s2.0-85143806365 | - |
dc.citation.endPage | 131 | - |
dc.citation.startPage | 121 | - |
dc.citation.title | International Journal of Biological Macromolecules | - |
dc.citation.volume | 226 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Hyaluronic acid | - |
dc.subject.keywordAuthor | Manganese dioxide | - |
dc.subject.keywordAuthor | T1 contrast agent | - |
dc.subject.keywordPlus | DIOXIDE NANOPARTICLES ENHANCE | - |
dc.subject.keywordPlus | MANGANESE-DIOXIDE | - |
dc.subject.keywordPlus | ALBUMIN-MNO2 NANOPARTICLES | - |
dc.subject.keywordPlus | CHLORIN E6 | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordPlus | NANOSHEETS | - |
dc.subject.keywordPlus | CELL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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