Food Restriction Augmented Alpha1-Adrenergic Mediated Contraction in Mesenteric Arteries
DC Field | Value | Language |
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dc.contributor.author | Vorn, Rany | - |
dc.contributor.author | Yoo, Hae Young | - |
dc.date.accessioned | 2023-02-10T03:41:36Z | - |
dc.date.available | 2023-02-10T03:41:36Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1099-8004 | - |
dc.identifier.issn | 1552-4175 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/60413 | - |
dc.description.abstract | Food restriction (FR) enhances sensitivity to cardiopulmonary reflexes and alpha 1-adrenoreceptors in females in the presence of hypotension. However, the effect of FR on cardiopulmonary and vascular function in males is not well-understood. This study examines the effects of FR on cardiopulmonary, isolated arterial function, and potential underlying mechanisms. Male Sprague-Dawley (SD) rats were randomly divided into 3 groups and monitored for 5 weeks: (1) control (n = 30), (2) 20% food reduction (FR20, n = 30), and (3) 40% food reduction (FR40, n = 30). Non-invasive blood pressure was measured twice a week. Pulmonary arterial pressure (PAP) was measured using isolated/perfused lungs. The isolated vascular reactivity was assessed using double-wire myographs. FR rats exhibited a lower mean arterial pressure and heart rate; however, only the FR40 group exhibited statistically significant differences. We observed that FR enhanced sensitivity (EC50) to vasoconstriction induced by the alpha 1-adrenoreceptor phenylephrine (PhE) but not to serotonin, U46619, or high K+ in the mesenteric arteries. PhE-mediated vasoconstriction in the mesenteric arteries was eliminated in the presence of the eNOS inhibitor (L-NAME). In addition, incubation with NOX2/4 inhibitors (apocynin, GKT137831, and VAS2870) and the reactive oxygen species (ROS) scavenger inhibitor (Tiron) eliminated the differences in PhE-mediated vasoconstriction, but the cyclooxygenase inhibitor (indomethacin) in the mesenteric arteries did not. Augmentation of alpha 1-adrenergic-mediated contraction via the inhibition of the eNOS-NO pathway increased the activation of ROS through NOX2/4 in response to FR. Reduced eNOS-NO signaling may be a pathophysiological counterbalance to prevent hypovolemic shock in response to FR. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Food Restriction Augmented Alpha1-Adrenergic Mediated Contraction in Mesenteric Arteries | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/10998004221132247 | - |
dc.identifier.bibliographicCitation | BIOLOGICAL RESEARCH FOR NURSING, v.25, no.2, pp 198 - 209 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000864896500001 | - |
dc.identifier.scopusid | 2-s2.0-85139415754 | - |
dc.citation.endPage | 209 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 198 | - |
dc.citation.title | BIOLOGICAL RESEARCH FOR NURSING | - |
dc.citation.volume | 25 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | food restriction | - |
dc.subject.keywordAuthor | vascular reactivity | - |
dc.subject.keywordAuthor | endothelial dysfunction | - |
dc.subject.keywordPlus | HYPOXIC PULMONARY VASOCONSTRICTION | - |
dc.subject.keywordPlus | CALORIE RESTRICTION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | ENDOTHELIAL DYSFUNCTION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordPlus | OBESITY | - |
dc.relation.journalResearchArea | Nursing | - |
dc.relation.journalWebOfScienceCategory | Nursing | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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