Establishment of Reference Intervals of Cytokeratin 19 Fragment Antigen 21-1 in Korean Adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Sumi | - |
dc.contributor.author | Lim, Yong Kwan | - |
dc.contributor.author | Kim, Hye Ryoun | - |
dc.contributor.author | Lee, Mi-Kyung | - |
dc.contributor.author | Kweon, Oh Joo | - |
dc.date.accessioned | 2023-03-08T04:47:57Z | - |
dc.date.available | 2023-03-08T04:47:57Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2234-3806 | - |
dc.identifier.issn | 2234-3814 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61117 | - |
dc.description.abstract | Cytokeratin 19 fragment antigen 21-1 (CYFRA 21-1) is useful for predicting and monitoring non-small cell lung cancer prognosis. We established reference intervals (RIs) of CYFRA 21-1 in Korean adults, including those older than 60 years. Data of 4,098 apparently healthy subjects (age range, 20-87 years) were analyzed after excluding those with a history of malignancy, high tumor marker concentrations (except CYFRA 21-1), and/or abnormal findings on a chest computed tomography scan through medical chart review. After removing two outliers, RIs of CYFRA 21-1 were determined using data of 4,096 subjects based on the non-parametric method (2.5th and 97.5th percentiles) according to CLSI guidelines EP28-A3c. The subjects were divided into two and four groups according to sex and age (20-40, 41-50, 51-60, and >60 years), respectively, and the median CYFRA 21-1 concentration was compared between the groups. The RI of CYFRA 21-1 was 0.66-3.84 ng/mL, applicable to both men and women. Regardless of sex, the CYFRA 21-1 concentration increased with age, suggesting that age-dependent RIs of CYFRA 21-1 should be applied. Rather than using a single RI provided by the manufacturer, the RI of CYFRA 21-1 should be continually verified and established in each clinical laboratory. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Establishment of Reference Intervals of Cytokeratin 19 Fragment Antigen 21-1 in Korean Adults | - |
dc.type | Article | - |
dc.identifier.doi | 10.3343/alm.2023.43.1.82 | - |
dc.identifier.bibliographicCitation | Annals of laboratory medicine, v.43, no.1, pp 82 - 85 | - |
dc.identifier.kciid | ART002905733 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000877222600002 | - |
dc.identifier.scopusid | 2-s2.0-85137047666 | - |
dc.citation.endPage | 85 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 82 | - |
dc.citation.title | Annals of laboratory medicine | - |
dc.citation.volume | 43 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Adult | - |
dc.subject.keywordAuthor | Age | - |
dc.subject.keywordAuthor | CYFRA 21-1 | - |
dc.subject.keywordAuthor | Korean | - |
dc.subject.keywordAuthor | Reference interval | - |
dc.subject.keywordAuthor | Sex | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.