Efficacy of Quantitative Pupillary Light Reflex for Predicting Neurological Outcomes in Patients Treated with Targeted Temperature Management after Cardiac Arrest: A Systematic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Kim, Jae-Guk | - |
dc.contributor.author | Shin, Hyungoo | - |
dc.contributor.author | Lim, Tae-Ho | - |
dc.contributor.author | Kim, Wonhee | - |
dc.contributor.author | Cho, Youngsuk | - |
dc.contributor.author | Jang, Bo-Hyoung | - |
dc.contributor.author | Choi, Kyu-Sun | - |
dc.contributor.author | Na, Min-Kyun | - |
dc.contributor.author | Ahn, Chiwon | - |
dc.contributor.author | Lee, Juncheol | - |
dc.date.accessioned | 2023-03-08T06:53:47Z | - |
dc.date.available | 2023-03-08T06:53:47Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.issn | 1648-9144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61292 | - |
dc.description.abstract | Background and objectives: This study aims to evaluate the usefulness of the quantitative pupillary light reflex as a prognostic tool for neurological outcomes in post-cardiac arrest patients treated with targeted temperature management (TTM). Material and Methods: We systematically searched MEDLINE, EMBASE, and the Cochrane Library (search date: 9 July 2021) for studies on post-cardiac arrest patients treated with TTM that had measured the percent constriction of pupillary light reflex (%PLR) with quantitative pupillometry as well as assessed the neurological outcome. For an assessment of the methodological quality of the included studies, two authors utilized the prognosis study tool independently. Results: A total of 618 patients from four studies were included in this study. Standardized mean differences (SMDs) were calculated to compare patients with good or poor neurological outcomes. A higher %PLR measured at 0-24 h after hospital admission was related to good neurological outcomes at 3 months in post-cardiac arrest patients treated with TTM (SMD 0.87; 95% confidence interval 0.70-1.05; I-2 = 0%). A higher %PLR amplitude measured at 24-48 h after hospital admission was also associated with a good neurological outcome at 3 months in post-cardiac arrest patients treated with TTM, but with high heterogeneity (standardized mean difference 0.86; 95% confidence interval 0.40-1.32; I-2 = 70%). The evidence supporting these findings was of poor quality. For poor neurological outcome, the prognosis accuracy of %PLR was 9.19 (pooled diagnostic odds ratio, I-2 = 0%) and 0.75 (area under the curve). Conclusions: The present meta-analysis could not reveal that change of %PLR was an effective tool in predicting neurological outcomes for post-cardiac arrest patients treated with TTM owing to a paucity of included studies and the poor quality of the evidence. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Efficacy of Quantitative Pupillary Light Reflex for Predicting Neurological Outcomes in Patients Treated with Targeted Temperature Management after Cardiac Arrest: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/medicina58060804 | - |
dc.identifier.bibliographicCitation | MEDICINA-LITHUANIA, v.58, no.6 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000815992200001 | - |
dc.identifier.scopusid | 2-s2.0-85132759503 | - |
dc.citation.number | 6 | - |
dc.citation.title | MEDICINA-LITHUANIA | - |
dc.citation.volume | 58 | - |
dc.type.docType | Review | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | pupillometry | - |
dc.subject.keywordAuthor | targeted temperature management | - |
dc.subject.keywordAuthor | heart arrest | - |
dc.subject.keywordAuthor | patient outcome assessment | - |
dc.subject.keywordAuthor | me-ta-analysis | - |
dc.subject.keywordPlus | INFRARED PUPILLOMETRY | - |
dc.subject.keywordPlus | PROGNOSTICATION | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | COMA | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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