Ameliorating the efficacy of galacto-oligosaccharides on ovalumin-induced allergic dermatitis symptoms in Balb/c mice by regulating Th2 immune response and the ecosystem of gut microbiota
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Kisoo | - |
dc.contributor.author | Ahn, Yejin | - |
dc.contributor.author | Hong, Ki-Bae | - |
dc.contributor.author | Suh, Hyung Joo | - |
dc.contributor.author | Yu, Kwang-Won | - |
dc.contributor.author | Kim, Hoon | - |
dc.date.accessioned | 2023-03-08T06:54:49Z | - |
dc.date.available | 2023-03-08T06:54:49Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 2042-650X | - |
dc.identifier.issn | 2042-6496 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61305 | - |
dc.description.abstract | In this study, we evaluated the effect of oral administration of galacto-oligosaccharide (GOS), famous biological molecules that are comprised of galactose and lactose, on ovalbumin (OVA)-induced allergic dermatitis. OVA-induced mice were divided into the OVA-administered group (OVA-C), promethazine hydrochloride-administered group (PC), and 100 and 200 mg kg(-1) GOS-administered groups (GL and GH, respectively). GOS administration significantly improved epidermal thickness and decreased CD4(+) cell numbers. The concentrations of IgE, OVA-specific IgE, and inflammatory cytokines (IL-4, IL-5, and INF-gamma) in GH group mice were significantly lower than those in OVA-C group mice. Firmicutes and Bacteroidetes were identified as the major phyla in the intestinal microbiota in mice, and the relative abundance of Deferribacteres was significantly lower in the GH group than in the OVA-C group. Deferribacteraceae and Mucispirillum species were significantly lower in the GH group than in the OVA-C group. The relative abundance of Muribaculum species was significantly lower, but those of Lachnospira and Lactococcus species were significantly higher in the GH group than in the OVA-C group. Our results suggest that the alleviation effect of GOS on allergic dermatitis induced by OVA sensitization was achieved by regulating hypersensitive immune responses by improving the intestinal microbial ecosystem. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Ameliorating the efficacy of galacto-oligosaccharides on ovalumin-induced allergic dermatitis symptoms in Balb/c mice by regulating Th2 immune response and the ecosystem of gut microbiota | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d2fo00157h | - |
dc.identifier.bibliographicCitation | FOOD & FUNCTION, v.13, no.11, pp 6271 - 6281 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000798864000001 | - |
dc.identifier.scopusid | 2-s2.0-85131702348 | - |
dc.citation.endPage | 6281 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 6271 | - |
dc.citation.title | FOOD & FUNCTION | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | ATOPIC-DERMATITIS | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | MIXTURE | - |
dc.subject.keywordPlus | MODEL | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.