Effects of ramosetron orally disintegrating tablets on the prophylaxis of post-discharge nausea and/or vomiting in female patients undergoing day surgery under general anesthesia: a randomized controlled trial
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyun-Jung | - |
dc.contributor.author | Park, Yong-Hee | - |
dc.contributor.author | Chang, Minying | - |
dc.contributor.author | Chae, Yun Jeong | - |
dc.contributor.author | Lee, Hun-Taek | - |
dc.contributor.author | Lee, Oh Haeng | - |
dc.contributor.author | Min, Sang-Kee | - |
dc.contributor.author | Do, Sang-Hwan | - |
dc.date.accessioned | 2023-03-08T07:22:11Z | - |
dc.date.available | 2023-03-08T07:22:11Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 2047-0525 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61388 | - |
dc.description.abstract | Background This study was performed to evaluate the effectiveness of ramosetron orally disintegrating tablets (ODTs) in preventing post-discharge nausea and/or vomiting (PDNV) in female patients following outpatient surgery under general anesthesia. Methods This multicenter randomized study included three South Korean tertiary hospitals. Before surgery, 138 patients were randomly allocated into two groups. In the ramosetron group, ramosetron ODT 0.1 mg was administered after discharge in the morning of postoperative days 1 and 2. Metoclopramide 10 mg was administered as a rescue antiemetic (capped at 30 mg per day). In the control group, patients were administered only metoclopramide 10 mg when nausea and/or vomiting occurred. The primary outcome was the incidence of nausea during 24 h after discharge. Results We found significant differences in the incidence (13% vs. 33%, P = 0.008) and severity (P = 0.011) of nausea between the ramosetron and the control groups during 24 h after discharge. In addition, the rate of rescue antiemetic (metoclopramide) administration during 24 h after discharge was lower in the ramosetron group (6%) than in the control group (18%) (P = 0.033). Patient satisfaction score was higher in the ramosetron group than in the control group (P < 0.001). Conclusion Ramosetron ODT reduces the incidence and severity of postoperative nausea after discharge during the first 24 h and may be a valuable option for the prevention of PDNV in female patients after day surgery under general anesthesia. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Effects of ramosetron orally disintegrating tablets on the prophylaxis of post-discharge nausea and/or vomiting in female patients undergoing day surgery under general anesthesia: a randomized controlled trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13741-022-00251-6 | - |
dc.identifier.bibliographicCitation | PERIOPERATIVE MEDICINE, v.11, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000793837900001 | - |
dc.citation.number | 1 | - |
dc.citation.title | PERIOPERATIVE MEDICINE | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Ramosetron | - |
dc.subject.keywordAuthor | Post-discharge | - |
dc.subject.keywordAuthor | Nausea | - |
dc.subject.keywordAuthor | Vomiting | - |
dc.subject.keywordAuthor | Outpatient surgery | - |
dc.subject.keywordPlus | POSTOPERATIVE NAUSEA | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ANALGESIA | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | scie | - |
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