Efficient Nicotinamide Adenine Dinucleotide Regeneration with a Rhodium-Carbene Catalyst and Isolation of a Hydride Intermediate
DC Field | Value | Language |
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dc.contributor.author | Ganesan, Vinothkumar | - |
dc.contributor.author | Kim, Jennifer Juhyun | - |
dc.contributor.author | Shin, Jeongcheol | - |
dc.contributor.author | Park, Kiyoung | - |
dc.contributor.author | Yoon, Sungho | - |
dc.date.accessioned | 2023-03-08T07:49:48Z | - |
dc.date.available | 2023-03-08T07:49:48Z | - |
dc.date.issued | 2022-04 | - |
dc.identifier.issn | 0020-1669 | - |
dc.identifier.issn | 1520-510X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61485 | - |
dc.description.abstract | Regeneration of nicotinamide adenine dinucleotide (NADH) has been the primary interest in the field of enzymatic transformation, especially associating oxidoreductases given the stoichiometric consumption. The synthesized carbene-ligated rhodium complex [(η5-Cp*)Rh(MDI)Cl]+ [Cp* = pentamethylcyclopentadienyl; MDI = 1,1'-methylenebis(3,3'-dimethylimidazolium)] acts as an exceptional catalyst in the reduction of NAD+ to NADH with a turnover frequency of 1730 h-1, which is over twice that of the higher catalytic activity of the commercially available catalyst [Cp*Rh(bpy)Cl]+ (bpy = 2,2'-bipyridine). Offsetting the contentious atmosphere currently taking place over the specific intermediate of the NADH regeneration, this study presents pivotal evidence of a metal hydride intermediate with a bis(carbene) ligand: a stable form of the rhodium hydride intermediate, [(η5-Cp*)Rh(MDI)H]+, was isolated and fully characterized. This enables thorough insight into the possible mechanism and exact intermediate structure in the NAD+ reduction process. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Efficient Nicotinamide Adenine Dinucleotide Regeneration with a Rhodium-Carbene Catalyst and Isolation of a Hydride Intermediate | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.inorgchem.2c00059 | - |
dc.identifier.bibliographicCitation | Inorganic chemistry, v.61, no.15, pp 5683 - 5690 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000791949700001 | - |
dc.identifier.scopusid | 2-s2.0-85128488024 | - |
dc.citation.endPage | 5690 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5683 | - |
dc.citation.title | Inorganic chemistry | - |
dc.citation.volume | 61 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | BIOORGANOMETALLIC CHEMISTRY | - |
dc.subject.keywordPlus | REGIOSELECTIVE REDUCTION | - |
dc.subject.keywordPlus | RHODIUM(III) COMPLEXES | - |
dc.subject.keywordPlus | NAD(P)-DEPENDENT OXIDOREDUCTASES | - |
dc.subject.keywordPlus | ENANTIOSELECTIVE REDUCTION | - |
dc.subject.keywordPlus | ELECTROCHEMICAL PROPERTIES | - |
dc.subject.keywordPlus | POTENTIAL APPLICATIONS | - |
dc.subject.keywordPlus | MECHANISTIC ASPECTS | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURES | - |
dc.subject.keywordPlus | NADH REGENERATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Inorganic & Nuclear | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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