라텍스 응집 검사를 이용한 Candida albicans와 Candida dubliniensis의 감별

Abstract

Background: Candida dubliniensis is phenotypically similar to Candida albicans that may be underdiagnosed in clinical laboratory. In 2010, C. dubliniensis was first recovered from blood of a candidemia patient in Seoul, Korea. Also, a simple commercial latex agglutination (LA) test is available. Objective: The aim of the present study was to investigate the prevalence of C. dubliniensis among isolates in our stocks during 2-years period (2010-2011) and to evaluate the ability of LA test (Bichro-Dubli Fumouze®) for the differentiation of C. albicans and C. dubliniensis. Methods: A total 509 isolates including 504 C. albicans and 5 C. dubliniensis were examined for LA test, the presence of spiking on blood agar plate, and the germ tube test. Also all isolates were tested using the VITEK 2ID-YST system. Results: No C. dubliniensis was found in 504 isolates of initially identified as C. albicans. The LA test was positive only in 5 clinical isolates and 2 type strains of C. dubliniensis. Conclusions: The data show that the prevalence of C. dubliniensis in Korea is still expected to be extremely low and LA test is very rapid, simple, and reliable tool for the differentiation of C. albicans and C dubliniensis. Copyright © 2017 by The Korean Society for Medical Mycology.