Flat Pattern Peaks of Tacrolimus Absorption and Associated Pharmacogenomic Variants in Kidney Transplantation Recipients
DC Field | Value | Language |
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dc.contributor.author | Kim Suh Min | - |
dc.contributor.author | Lim Younggyun | - |
dc.contributor.author | Min Sangil | - |
dc.contributor.author | Min Byung-Joo | - |
dc.contributor.author | Seo Myung-Eui | - |
dc.contributor.author | Lee Kye Hwa | - |
dc.contributor.author | Kim Ju Han | - |
dc.contributor.author | Ha Jongwon | - |
dc.date.accessioned | 2023-03-08T08:36:32Z | - |
dc.date.available | 2023-03-08T08:36:32Z | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61620 | - |
dc.description.abstract | Background: Tacrolimus is the most commonly used immunosuppressive drug in solid organ transplantation. After administering a conventional twice-daily dose of tacrolimus, peak levels were achieved within the first 1.5 to 2 hours. A group of patients showed different early absorption phase of tacrolimus after kidney transplantation. Methods: Trough(C0) and 1.5-hour blood levels (C1.5) of tacrolimus were measured in 95 kidney transplantation recipients. Patients with a C1.5/C0 < 1.5 and > 1.5 were defined as those having flat pattern peaks and as controls, respectively. Transplantation outcomes were compared between the groups. Whole exome sequencing was performed to investigate the genetic susceptibility to flat pattern peaks. Results: Twenty-eight patients showed flat pattern peaks. The mean C1.5/C0 values were 1.13 ± 0.22 and 3.78 ± 1.25 in the flat pattern peak and control groups, respectively. In multivariate analysis, flat pattern peak was an independent risk factor for biopsy-proven acute rejection (BPAR) and/or borderline change (P = 0.014). Patients having flat pattern peaks showed significantly lower post-transplant 36-month estimated glomerular filtration rate (P = 0.001). Two single nucleotide variants in ABCB1 genes, rs1922242 and rs2235035, were associated with flat pattern peaks (P = 0.019 and P = 0.027, respectively). Conclusion: Both of C1.5 and C0 should be measured to distinguish the patients showing unique initial absorption. A C1.5/C0 ratio lower than 1.5 was associated with an increased risk of BPAR and/or borderline change. Single nucleotide variants s in ABCB1 gene might influence the flat pattern peaks of tacrolimus absorption. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한의학회 | - |
dc.title | Flat Pattern Peaks of Tacrolimus Absorption and Associated Pharmacogenomic Variants in Kidney Transplantation Recipients | - |
dc.title.alternative | Flat Pattern Peaks of Tacrolimus Absorption and Associated Pharmacogenomic Variants in Kidney Transplantation Recipients | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2022.37.e33 | - |
dc.identifier.bibliographicCitation | Journal of Korean Medical Science, v.37, no.5, pp 1 - 11 | - |
dc.identifier.kciid | ART002809880 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000753561100001 | - |
dc.identifier.scopusid | 2-s2.0-85124286146 | - |
dc.citation.endPage | 11 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Journal of Korean Medical Science | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Tacrolimus | - |
dc.subject.keywordAuthor | Kidney Transplantation | - |
dc.subject.keywordAuthor | Pharmacogenomics | - |
dc.subject.keywordPlus | CALCINEURIN INHIBITORS | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | PHARMACODYNAMICS | - |
dc.subject.keywordPlus | POLYMORPHISMS | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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