High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip
DC Field | Value | Language |
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dc.contributor.author | Khalid, Muhammad Asad Ullah | - |
dc.contributor.author | Kim, Kyung Hwan | - |
dc.contributor.author | Salih, Abdul Rahim Chethikkattuveli | - |
dc.contributor.author | Hyun, Kinam | - |
dc.contributor.author | Park, Sung Hyuk | - |
dc.contributor.author | Kang, Bohye | - |
dc.contributor.author | Soomro, Afaque Manzoor | - |
dc.contributor.author | Ali, Muhsin | - |
dc.contributor.author | Jun, Yesl | - |
dc.contributor.author | Huh, Dongeun | - |
dc.contributor.author | Cho, Heeyeong | - |
dc.contributor.author | Choi, Kyung Hyun | - |
dc.date.accessioned | 2023-03-08T08:40:08Z | - |
dc.date.available | 2023-03-08T08:40:08Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.issn | 1473-0189 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61637 | - |
dc.description.abstract | Sensing devices have shown tremendous potential for monitoring state-of-the-art organ chip devices. However, challenges like miniaturization while maintaining higher performance, longer operating times for continuous monitoring, and fabrication complexities limit their use. Herein simple, low-cost, and solution-processible inkjet dispenser printing of embedded electrochemical sensors for dissolved oxygen (DO) and reactive oxygen species (ROS) is proposed for monitoring developmental (initially normoxia) and induced hypoxia in a custom-developed gut bilayer microfluidic chip platform for 6 days. The DO sensors showed a high sensitivity of 31.1 nA L mg(-1) with a limit of detection (LOD) of 0.67 mg L-1 within the 0-9 mg L-1 range, whereas the ROS sensor had a higher sensitivity of 1.44 nA mu m(-1) with a limit of detection of 1.7 mu m within the 0-300 mu m range. The dynamics of the barrier tight junctions are quantified with the help of an in-house developed trans-epithelial-endothelial electrical impedance (TEEI) sensor. Immunofluorescence staining was used to evaluate the expressions of HIF-1 alpha and tight junction protein (TJP) ZO-1. This platform can also be used to enhance bioavailability assays, drug transport studies under an oxygen-controlled environment, and even other barrier organ models, as well as for various applications like toxicity testing, disease modeling and drug screening. | - |
dc.format.extent | 15 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | High performance inkjet printed embedded electrochemical sensors for monitoring hypoxia in a gut bilayer microfluidic chip | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d1lc01079d | - |
dc.identifier.bibliographicCitation | LAB ON A CHIP, v.22, no.9, pp 1764 - 1778 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000764228300001 | - |
dc.identifier.scopusid | 2-s2.0-85127053415 | - |
dc.citation.endPage | 1778 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1764 | - |
dc.citation.title | LAB ON A CHIP | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | ORGANS-ON-CHIPS | - |
dc.subject.keywordPlus | ELECTRICAL-RESISTANCE TEER | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | CELLS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Instruments & Instrumentation | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Instruments & Instrumentation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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