Impulsivity in persons with epilepsy: Association with seizure severity and suicide risk
DC Field | Value | Language |
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dc.contributor.author | Lee, S.-A. | - |
dc.contributor.author | Choi, E.J. | - |
dc.contributor.author | Jeon, J.-Y. | - |
dc.contributor.author | Han, S.-H. | - |
dc.contributor.author | Kim, H.-W. | - |
dc.contributor.author | Lee, G.-H. | - |
dc.contributor.author | Ryu, H.U. | - |
dc.contributor.author | Im, K. | - |
dc.contributor.author | Yang, H.-R. | - |
dc.date.accessioned | 2023-03-08T09:24:19Z | - |
dc.date.available | 2023-03-08T09:24:19Z | - |
dc.date.issued | 2022-01 | - |
dc.identifier.issn | 0920-1211 | - |
dc.identifier.issn | 1872-6844 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/61797 | - |
dc.description.abstract | Purpose: Clinical research regarding impulsivity in patients with epilepsy is limited. The present study investigated the associations between impulsivity and seizure-related factors or suicidality in patients with epilepsy, independent of depression and anxiety. Methods: The multicenter study included 146 subjects (63% men). We utilized the Barratt Impulsiveness Scale-11 (BIS-11), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and suicidality module of the Mini International Neuropsychiatric Interview (MINI). Stepwise regression analyses and an analysis of covariance with interaction terms were performed. Results: The mean BIS-11 score was 59.3 (SD = 10.7). Psychiatric pathologies, including suicidality, were reported in relatively large proportions of patients, including PHQ-9 score ≥ 10 in 29 (19.9%) patients, GAD-7 score ≥ 7 in 35 (24.0%) patients, and MINI suicidality score ≥ 6 in 15 (10.3%) patients. Stepwise linear regression revealed that BIS-11 score was positively associated with the PHQ-9 scores (p < 0.001), antiseizure medication polytherapy (p < 0.001), use of lamotrigine (p = 0.009), and recurrence of generalized or focal to bilateral tonic clonic seizures (p = 0.010). The coefficient of determination for the model was 0.397. Generalized or focal to bilateral tonic clonic seizure recurrence tended to be positively associated with total BIS-11 scores in men but not in women. In subscale analyses, somewhat different variables were associated with different BIS-11subscales. A trend for a positive association between BIS-11 score and suicidality was found (p = 0.066). Conclusions: This study identified a positive association between clinical seizure severity and impulsivity, and found that this association tended to be sex-specific, occurring only in males. Impulsivity could potentially be weakly associated with suicidality in patients with epilepsy. © 2021 Elsevier B.V. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Impulsivity in persons with epilepsy: Association with seizure severity and suicide risk | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.eplepsyres.2021.106825 | - |
dc.identifier.bibliographicCitation | Epilepsy Research, v.179 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000786582400001 | - |
dc.identifier.scopusid | 2-s2.0-85120404309 | - |
dc.citation.title | Epilepsy Research | - |
dc.citation.volume | 179 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Aggression | - |
dc.subject.keywordAuthor | Antiepileptic drug | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Polytherapy | - |
dc.subject.keywordAuthor | Suicidality | - |
dc.subject.keywordAuthor | Trait impulsivity | - |
dc.subject.keywordPlus | FEMALE BORDERLINE-PATIENTS | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | PREMEDITATED AGGRESSION | - |
dc.subject.keywordPlus | LAMOTRIGINE TREATMENT | - |
dc.subject.keywordPlus | ILAE COMMISSION | - |
dc.subject.keywordPlus | POSITION PAPER | - |
dc.subject.keywordPlus | PLACEBO | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | LEVETIRACETAM | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scopus | - |
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