M13 박테리오파지 기반의 바이오센서 개발

Abstract

A biosensor is an analytic microsystem in which a biological component is coupled with a transducer to convert biological signal into an electrical out. Utilization of biosensors has been considered the importance in the field of drug discovery, biomedicine, food safety, biodefense with security, and environmental monitoring. Recently, interest in biosensor is still increasing, and it needs to develop more advanced biosensor that capable of any of targets with high sensitivity and selectivity. Therefore, it is necessary to discover new bioreceptors with high sensitivity and selectivity. Bacteriophage, especially M13 bacteriophages, are emerging as new biological receptors. The peptide-displayed M13 bacteriophage not only could specifically and selectively bind to desired target molecules but also easily manipulate genetical and/or chemical modification in biosensor applications. Therefore, we summarize recent advances and the possibilities of biosensor development utilizing M13 bacteriophages.