Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways
DC Field | Value | Language |
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dc.contributor.author | Kim, H. | - |
dc.contributor.author | Lim, J.-J. | - |
dc.contributor.author | Shin, H.Y. | - |
dc.contributor.author | Suh, H.J. | - |
dc.contributor.author | Choi, H.-S. | - |
dc.date.accessioned | 2023-03-08T10:03:02Z | - |
dc.date.available | 2023-03-08T10:03:02Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62029 | - |
dc.description.abstract | Paraprobiotics are non-viable cells or cell fractions that have beneficial effects on the host; they may help in overcoming the limitations of probiotics and expanding their benefits. Here, we aimed to investigate their effects on lipid accumulation and the underlying mechanisms in 3T3-L1 preadipocytes. A novel paraprobiotic, LAB-P, prepared from the live cells of Lactobacillus plantarum K8, effectively inhibited lipid accumulation during adipogenesis via downregulation of the key activators PPARγ and C/EBPα. LAB-P-mediated reduction of lipid accumulation regulated early adipogenic factors, including downregulation of C/EBPβ, KLF4, KLF5, KROX20, and C/EBPδ, and upregulation of DLK1. Western blotting analysis revealed that these inhibitory effects of LAB-P on adipogenesis were associated with regulating JAK-STAT and AMPKα signaling pathways. This study highlights the potential of paraprobiotics as a functional food material to control obesity or obesity-related diseases, and provides valuable groundwork for utilizing LAB-P as a functional ingredient to alleviate obesity or lipid accumulation. © 2021 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Lactobacillus plantarum K8-based paraprobiotics suppress lipid accumulation during adipogenesis by the regulation of JAK/STAT and AMPK signaling pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jff.2021.104824 | - |
dc.identifier.bibliographicCitation | Journal of Functional Foods, v.87 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000715048700003 | - |
dc.identifier.scopusid | 2-s2.0-85118122227 | - |
dc.citation.title | Journal of Functional Foods | - |
dc.citation.volume | 87 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Adipogenesis | - |
dc.subject.keywordAuthor | AMPKα | - |
dc.subject.keywordAuthor | JAK/STAT | - |
dc.subject.keywordAuthor | Obesity | - |
dc.subject.keywordAuthor | Paraprobiotics | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | STIMULATES ADIPOGENESIS | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | C/EBP-BETA | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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