Development of surface-enhanced Raman scattering-based immunoassay platforms using hollow Au nanostars for reliable SARS-CoV-2 diagnosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Qian | - |
dc.contributor.author | Wu, Yixuan | - |
dc.contributor.author | Kang, Taejoon | - |
dc.contributor.author | Choo, Jaebum | - |
dc.date.accessioned | 2023-03-08T10:03:17Z | - |
dc.date.available | 2023-03-08T10:03:17Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.issn | 1229-5949 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62032 | - |
dc.description.abstract | We developed a novel surface-enhanced Raman scattering (SERS)-based SARS-CoV-2 assay platform using hollow Au nanostars to realize high-sensitivity diagnosis of SARS-CoV-2. The assay was performed using SARS-CoV-2 lysate as the target in a wide dynamic range with virus concentrations ranging from 0 to 104 PFU/ml and has a limit of detection (LOD) of 5.1 PFU/ml. This LOD value shows 100 times and 10 times better sensitivity compared to the LODs measured on the same sample using a commercially available rapid kit and enzyme-linked immunosorbent assay, respectively. Therefore, we believe that this SERS-based SARS-CoV-2 assay platform has high diagnostic accuracy for early or asymptomatic infected patients with low virus concentrations. Furthermore, the probability of a false-negative diagnosis is likely to be very low. © 2021 Korean Chemical Society, Seoul & Wiley-VCH GmbH | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Development of surface-enhanced Raman scattering-based immunoassay platforms using hollow Au nanostars for reliable SARS-CoV-2 diagnosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/bkcs.12418 | - |
dc.identifier.bibliographicCitation | Bulletin of the Korean Chemical Society, v.42, no.12, pp 1699 - 1705 | - |
dc.identifier.kciid | ART002786131 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000707148700001 | - |
dc.identifier.scopusid | 2-s2.0-85117038110 | - |
dc.citation.endPage | 1705 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1699 | - |
dc.citation.title | Bulletin of the Korean Chemical Society | - |
dc.citation.volume | 42 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | hollow gold nanostar | - |
dc.subject.keywordAuthor | immunoassay | - |
dc.subject.keywordAuthor | magnetic bead | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | surface-enhanced Raman scattering | - |
dc.subject.keywordPlus | GOLD | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | RESONANCE | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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