Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala
DC Field | Value | Language |
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dc.contributor.author | Park, Kwan Hee | - |
dc.contributor.author | Yoon, Kyu Hyeong | - |
dc.contributor.author | Yin, Jun | - |
dc.contributor.author | Thi Tam Le | - |
dc.contributor.author | Ahn, Hye Sin | - |
dc.contributor.author | Yoon, Seong Hye | - |
dc.contributor.author | Lee, Min Won | - |
dc.date.available | 2019-03-08T11:56:20Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 1741-427X | - |
dc.identifier.issn | 1741-4288 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6208 | - |
dc.description.abstract | Chromatographic isolation of the 80% MeOH extract of Acer ginnala (AG) yielded seven galloyl derivatives: gallic acid (1), ginnalin B (2), acertannin (3), maplexin D (4), maplexin E (5), quercetin-3-O-(2 ''-galloyl)-alpha-L-rhamnopyranoside (6), and kaempferol-3-O-(2 ''-galloyl)-alpha-L-rhamnopyranoside (7). This is the first study to report the isolation of compounds 4 and 5 from AG. Galloyl derivatives 3-7 exhibited potent radical scavenging activities, with 5 and 7 showing particularly strong inhibitory activities against nitric oxide production in lipopolysaccharides- (LPS-) stimulated RAW264.7 cells. In addition, oral administration of AG extract (500 mg/kg b.w.) improved symptoms of hyperglycemia and blunted the increases in serum GOT/GPT levels in a rat model of streptozotocin-induced diabetes. These results suggest that galloyl derivatives (1-7) are antioxidant and anti-inflammatory agents and that AG extract has potential as a functional material or novel herbal medicine for treating diabetes mellitus. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | HINDAWI LTD | - |
dc.title | Antioxidative and Anti-Inflammatory Activities of Galloyl Derivatives and Antidiabetic Activities of Acer ginnala | - |
dc.type | Article | - |
dc.identifier.doi | 10.1155/2017/6945912 | - |
dc.identifier.bibliographicCitation | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2017 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000397864500001 | - |
dc.identifier.scopusid | 2-s2.0-85015796881 | - |
dc.citation.title | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | - |
dc.citation.volume | 2017 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | MAPLE | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | STREPTOZOTOCIN | - |
dc.subject.keywordPlus | ACERTANNIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | RATS | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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