Increasing changes in visceral adiposity is associated with higher risk for colorectal adenoma: Multilevel analysis in a prospective cohort
- Authors
- Moon, Jung Min; Im, Jong Pil; Kim, Donghee; Han, Yoo Min; Soh, Hosim; Song, Ji Hyun; Yang, Sun Young; Kim, Young Sun; Yim, Jeong Yoon; Lim, Seon Hee; Kim, Joo Sung
- Issue Date
- Jul-2021
- Publisher
- WILEY
- Keywords
- cohort; colorectal polyp; longitudinal studies; visceral adipose tissue
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.36, no.7, pp 1836 - 1842
- Pages
- 7
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 36
- Number
- 7
- Start Page
- 1836
- End Page
- 1842
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62354
- DOI
- 10.1111/jgh.15364
- ISSN
- 0815-9319
1440-1746
- Abstract
- Background and Aim While many studies demonstrated an association between visceral adiposity and colorectal adenoma (CRA), the effect of longitudinal changes in body fat composition on CRA is unclear. We investigated the longitudinal association between changes in visceral adiposity and CRA occurrence. Methods Between 2006 and 2018, 732 (62.8%) of the 1165 subjects in a prospective cohort voluntarily underwent follow-up abdominal fat computed tomography and colonoscopy. We defined incident and recurrent CRA as adenoma detected at follow-up colonoscopy from negative and positive adenoma at baseline colonoscopy, respectively. Multilevel survival analysis examined the longitudinal association between changes in visceral fat and CRA. Results During a median follow-up of 7.4 years, 400 (54.6%) subjects developed CRA. In multivariable analysis, increasing changes in visceral adipose tissue (VAT) area were associated with higher risk of incident adenoma (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.00-1.46 for change per 10 cm(2) increase; HR 1.79, 95% CI 1.08-2.97 for highest vs lowest quartile, P values for trend = 0.045). Likewise, increasing changes in VAT area were independently associated with a higher risk of recurrent adenoma (HR 1.35, 95% CI 1.13-1.62 for change per 10 cm(2) increase; HR 1.62, 95% CI 1.04-2.52 for highest vs lowest quartile, P values for trend = 0.001). Changes in subcutaneous adipose tissue area were not independently associated with CRA. Conclusion Increasing changes in VAT area were longitudinally associated with a higher risk of incident and recurrent CRA, independent of risk factors, suggesting that visceral adiposity may be an important target in CRA prevention.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.