Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability
DC Field | Value | Language |
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dc.contributor.author | Lim, C. | - |
dc.contributor.author | Kang, J.K. | - |
dc.contributor.author | Jung, C.E. | - |
dc.contributor.author | Sim, T. | - |
dc.contributor.author | Her, J. | - |
dc.contributor.author | Kang, K. | - |
dc.contributor.author | Lee, E.S. | - |
dc.contributor.author | Youn, Y.S. | - |
dc.contributor.author | Choi, H.-G. | - |
dc.contributor.author | Oh, K.T. | - |
dc.date.accessioned | 2023-03-08T10:51:09Z | - |
dc.date.available | 2023-03-08T10:51:09Z | - |
dc.date.issued | 2021-06-02 | - |
dc.identifier.issn | 1530-9932 | - |
dc.identifier.issn | 1522-1059 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62364 | - |
dc.description.abstract | Lutein has been used as a dietary supplement for the treatment of eye diseases, especially age-related macular degeneration. For oral formulations, we investigated lutein stability in artificial set-ups mimicking different physiological conditions and found that lutein was degraded over time under acidic conditions. To enhance the stability of lutein upon oral intake, we developed enteric-coated lutein solid dispersions (SD) by applying a polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS-LF), through a solvent-controlled precipitation method. The SD were characterized in crystallinity, morphology, and drug entrapment. In the dissolution profile of lutein SD, a F80 formulation showed resistance toward the acidic environment under simulated gastric conditions while exhibiting a bursting drug release under simulated intestinal conditions. Our results highlight the potential use of HPMCAS-LF as an effective matrix to enhance lutein bioavailability during oral delivery and to provide novel insights into the eye-care supplement industry, with direct benefits for the health of patients. Graphical abstract: [Figure not available: see fulltext.]. © 2021, American Association of Pharmaceutical Scientists. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Science and Business Media Deutschland GmbH | - |
dc.title | Preparation and Characterization of a Lutein Solid Dispersion to Improve Its Solubility and Stability | - |
dc.type | Article | - |
dc.identifier.doi | 10.1208/s12249-021-02036-4 | - |
dc.identifier.bibliographicCitation | AAPS PharmSciTech, v.22, no.5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000765803400001 | - |
dc.identifier.scopusid | 2-s2.0-85107152944 | - |
dc.citation.number | 5 | - |
dc.citation.title | AAPS PharmSciTech | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | absorption | - |
dc.subject.keywordAuthor | bioavailability | - |
dc.subject.keywordAuthor | degradation | - |
dc.subject.keywordAuthor | lutein | - |
dc.subject.keywordAuthor | oral drug delivery | - |
dc.subject.keywordAuthor | pH sensitivity | - |
dc.subject.keywordAuthor | solid dispersion | - |
dc.subject.keywordAuthor | stability | - |
dc.subject.keywordPlus | hydroxypropylmethylcellulose acetate succinate | - |
dc.subject.keywordPlus | methylcellulose | - |
dc.subject.keywordPlus | polymer | - |
dc.subject.keywordPlus | solvent | - |
dc.subject.keywordPlus | xanthophyll | - |
dc.subject.keywordPlus | bioavailability | - |
dc.subject.keywordPlus | drug release | - |
dc.subject.keywordPlus | drug stability | - |
dc.subject.keywordPlus | high performance liquid chromatography | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | procedures | - |
dc.subject.keywordPlus | solubility | - |
dc.subject.keywordPlus | synthesis | - |
dc.subject.keywordPlus | X ray diffraction | - |
dc.subject.keywordPlus | Biological Availability | - |
dc.subject.keywordPlus | Chromatography, High Pressure Liquid | - |
dc.subject.keywordPlus | Drug Liberation | - |
dc.subject.keywordPlus | Drug Stability | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Lutein | - |
dc.subject.keywordPlus | Methylcellulose | - |
dc.subject.keywordPlus | Polymers | - |
dc.subject.keywordPlus | Solubility | - |
dc.subject.keywordPlus | Solvents | - |
dc.subject.keywordPlus | X-Ray Diffraction | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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