Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Hyuk-Kwon | - |
dc.contributor.author | Lee, Inkyu | - |
dc.contributor.author | Yu, Kristin E. | - |
dc.contributor.author | Cahill, Sean, V | - |
dc.contributor.author | Alder, Kareme D. | - |
dc.contributor.author | Lee, Saelim | - |
dc.contributor.author | Dussik, Christopher M. | - |
dc.contributor.author | Back, JungHo | - |
dc.contributor.author | Choi, Jeongjoon | - |
dc.contributor.author | Song, Lee | - |
dc.contributor.author | Kyriakides, Themis R. | - |
dc.contributor.author | Lee, Francis Y. | - |
dc.date.accessioned | 2023-03-08T10:52:31Z | - |
dc.date.available | 2023-03-08T10:52:31Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62377 | - |
dc.description.abstract | Bacterial infections involving joints and vital organs represent a challenging clinical problem because of the two concurrent therapeutic goals of bacterial eradication and tissue preservation. In the case of septic arthritis, permanent destruction of articular cartilage by intense host inflammation is commonly seen even after successful treatment of bacterial infection. Here, we provide scientific evidence of a novel treatment modality that can protect articular cartilage and enhanced eradication of causative bacteria in septic arthritis. Locally delivered cell-penetrating antibiotics such as rifampicin effectively eradicate intracellular reservoirs of methicillin-resistant Staphylococcus aureus within joint cells. Furthermore, mitigation of intra-articular inflammation by targeting the NLRP3 (nucleotide-binding oligomerization domain-, leucine-rich repeat- and pyrin domain-containing 3) inflammasome protects articular cartilage from damage in a murine model of knee septic arthritis. Together, concurrent mitigation of intra-articular inflammation and local adjuvant targeting of intracellular bacteria represents a promising new therapeutic strategy for septic arthritis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Dual therapeutic targeting of intra-articular inflammation and intracellular bacteria enhances chondroprotection in septic arthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciadv.abf2665 | - |
dc.identifier.bibliographicCitation | SCIENCE ADVANCES, v.7, no.26 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000669960200004 | - |
dc.citation.number | 26 | - |
dc.citation.title | SCIENCE ADVANCES | - |
dc.citation.volume | 7 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordPlus | ADULTS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.