Beneficial Effect of Left Ventricular Remodeling after Early Change of Sacubitril/Valsartan in Patients with Nonischemic Dilated Cardiomyopathy
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyue-Mee | - |
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Park, Jin-Sik | - |
dc.contributor.author | Oh, Byung-Hee | - |
dc.date.accessioned | 2023-03-08T11:00:01Z | - |
dc.date.available | 2023-03-08T11:00:01Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 1010-660X | - |
dc.identifier.issn | 1648-9144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62447 | - |
dc.description.abstract | Background and Objectives: Evidence for effectiveness of early change from angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme inhibitors (ACEIs) to sacubitril/valsartan is lacking. We aimed to investigate whether early changes to sacubitril/valsartan could improve outcomes in patients with nonischemic dilated cardiomyopathy (DCM) in real-world practice. Materials and Methods: A total of 296 patients with nonischemic DCM who were treated with ARB or ACEI continuously (group A, n = 150) or had their medication switched to sacubitril/valsartan (group S, n = 146) were included. The sacubitril/valsartan group was divided into early change (within 60 days, group S/E, n = 59) and late change (group S/L, n = 87) groups. Changes in echocardiographic parameters from the time of initial diagnosis to the last follow-up were analyzed. Results: Patients in group S showed greater left ventricular (LV) end-diastolic dimension (EDD) (group A vs. S, 61.7 +/- 7.4 vs. 66.5 +/- 8.0, p < 0.001) and lower LV ejection fraction (LVEF) (28.9 +/- 8.2% vs. 23.9 +/- 7.5%, p < 0.001) than those in group A at initial diagnosis. During a median follow-up of 76 months, patients in group S/E, increment LVEF (%) and increment LVESD (mm) were significantly improved compared with those in patients in group A (group A vs. S/E, increment LVEF, p = 0.036; increment LVESD, p = 0.023) or S/L (group S/E vs. S/L, increment LVEF, p = 0.05; increment LVESD, p = 0.005). Among patients whose medications were switched to sacubitril/valsartan, those with an earlier change showed a significant correlation with greater LVEF improvement (r = -0.367, p < 0.001) and LV reverse remodeling (r = 0.277, p < 0.001). Conclusions: in patients with nonischemic DCM, an early switch to sacubitril/valsartan was associated with greater improvement in LV function. Patients might benefit in terms of LV function by early switching to sacubitril/valsartan. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Beneficial Effect of Left Ventricular Remodeling after Early Change of Sacubitril/Valsartan in Patients with Nonischemic Dilated Cardiomyopathy | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/medicina57050416 | - |
dc.identifier.bibliographicCitation | MEDICINA-LITHUANIA, v.57, no.5 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000654279300001 | - |
dc.identifier.scopusid | 2-s2.0-85105234107 | - |
dc.citation.number | 5 | - |
dc.citation.title | MEDICINA-LITHUANIA | - |
dc.citation.volume | 57 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | sacubitril | - |
dc.subject.keywordAuthor | valsartan | - |
dc.subject.keywordAuthor | nonischemic dilated cardiomyopathy | - |
dc.subject.keywordAuthor | left ventricular remodeling | - |
dc.subject.keywordAuthor | heart failure | - |
dc.subject.keywordPlus | REDUCED EJECTION FRACTION | - |
dc.subject.keywordPlus | HEART-FAILURE | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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