C-11-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia
DC Field | Value | Language |
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dc.contributor.author | Youn, Young Chul | - |
dc.contributor.author | Jang, Jae-Won | - |
dc.contributor.author | Han, Su-Hyun | - |
dc.contributor.author | Kim, HyeRyoun | - |
dc.contributor.author | Seok, Ju-Won | - |
dc.contributor.author | Byun, Jun Soo | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.contributor.author | Chun, In Kook | - |
dc.contributor.author | Kim, Sangyun | - |
dc.date.available | 2019-03-08T11:57:00Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 1178-1998 | - |
dc.identifier.issn | 1178-1998 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6247 | - |
dc.description.abstract | Purpose: Early-onset Alzheimer's disease (EOAD) has a different pathologic burden and clinical features compared with late-onset Alzheimer's disease(LOAD). We examined the effects of age at onset on the burden and distribution of beta-amyloid in patients with EOAD, in whom well-characterized mutations associated with Alzheimer's disease were absent. Methods: We genotyped ApoE, APP, PSEN1 and PSEN2 in the patients with Alzheimer's disease: 9 patients with EOAD (age <65), 11 with LOAD (age >70) and 8 normal controls (NCs), all of whom had undergone C-11-labeled Pittsburgh compound B-positron emission tomography imaging. Results: Patients with EOAD exhibited higher z scores and larger cluster sizes, and retained higher levels of Pittsburgh compound B in the bilateral thalamus and in some parts of the globus pallidus (P<0.05, false discovery rate). Conclusion: Distribution of amyloid deposition in EOAD outside the context of genetic mutations topographically showed some differences from that in LOAD. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | DOVE MEDICAL PRESS LTD | - |
dc.title | C-11-PIB PET imaging reveals that amyloid deposition in cases with early-onset Alzheimer's disease in the absence of known mutations retains higher levels of PIB in the basal ganglia | - |
dc.type | Article | - |
dc.identifier.doi | 10.2147/CIA.S132884 | - |
dc.identifier.bibliographicCitation | CLINICAL INTERVENTIONS IN AGING, v.12, pp 1041 - 1048 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000404348200004 | - |
dc.identifier.scopusid | 2-s2.0-85024103899 | - |
dc.citation.endPage | 1048 | - |
dc.citation.startPage | 1041 | - |
dc.citation.title | CLINICAL INTERVENTIONS IN AGING | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.subject.keywordAuthor | Alzheimer's disease | - |
dc.subject.keywordAuthor | early-onset Alzheimer's disease | - |
dc.subject.keywordAuthor | amyloid PET | - |
dc.subject.keywordAuthor | basal ganglia | - |
dc.subject.keywordAuthor | Pittsburgh compound B | - |
dc.subject.keywordAuthor | amyloid | - |
dc.subject.keywordPlus | PATHOLOGY | - |
dc.subject.keywordPlus | COGNITION | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | GREATER | - |
dc.subject.keywordPlus | NUCLEI | - |
dc.subject.keywordPlus | BURDEN | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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