Variability of FP-CIT PET Patterns Associated With Clinical Features of Multiple System Atrophy
DC Field | Value | Language |
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dc.contributor.author | Lee, R. | - |
dc.contributor.author | Shin, J.H. | - |
dc.contributor.author | Choi, H. | - |
dc.contributor.author | Kim, H.-J. | - |
dc.contributor.author | Cheon, G.J. | - |
dc.contributor.author | Jeon, B. | - |
dc.date.accessioned | 2023-03-08T11:09:12Z | - |
dc.date.available | 2023-03-08T11:09:12Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.issn | 1526-632X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62543 | - |
dc.description.abstract | OBJECTIVE: To validate the role of the dopamine transporter (DAT) imaging as a biomarker in multiple system atrophy (MSA), we analyzed the association between spatial patterns of [18F]fluoro-propyl-carbomethoxy-iodophenyl-tropane ([18F]FP-CIT) PET and the clinical characteristics of MSA. METHODS: Sixty-five patients with MSA who underwent [18F]FP-CIT PET between 2009 and 2018 were retrospectively enrolled. To identify spatial patterns of [18F]FP-CIT PET, principal component (PC) analysis was used and correlated with the clinical presentation. RESULTS: Of the 65 patients, 42 presented with parkinsonian subtype of MSA, and 23 presented with cerebellar subtype of MSA (mean age 63.7 ± 9.3 years; disease duration, 1.8 ± 1.8 years). Each PC represents a specific pattern of degeneration: PC1 and PC2 were associated with the DAT binding of the entire putamen and the posterior putamen, respectively. PC3 was associated with increased [18F]FP-CIT uptake of the caudate and decreased uptake of the dorsal pons. PC2 was significantly correlated with the presence of parkinsonism (p = 5.34 × 10-5) and a positive levodopa response (p = 0.044), with age as a cofactor. PC3 was correlated with the presence of urinary incontinence (p = 0.036). Onset age was significantly correlated with both PC2 (R = 0.48, p = 5.0 × 10-5) and PC3 (R = -0.39, p = 0.0013). CONCLUSIONS: The spatial pattern of DAT binding can reflect distinct clinical features of MSA and provides insight into the underlying pathophysiology of a broad spectrum of clinical features in MSA. © 2021 American Academy of Neurology. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Variability of FP-CIT PET Patterns Associated With Clinical Features of Multiple System Atrophy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1212/WNL.0000000000011634 | - |
dc.identifier.bibliographicCitation | Neurology, v.96, no.12, pp e1663 - e1671 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000656633700021 | - |
dc.identifier.scopusid | 2-s2.0-85103474173 | - |
dc.citation.endPage | e1671 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e1663 | - |
dc.citation.title | Neurology | - |
dc.citation.volume | 96 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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