Association between arterial stiffness and the presence of cerebral small vessel disease markers
DC Field | Value | Language |
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dc.contributor.author | Bae, Jae-Han | - |
dc.contributor.author | Kim, Jeong-Min | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Han, Su-Hyun | - |
dc.date.accessioned | 2023-03-08T11:46:54Z | - |
dc.date.available | 2023-03-08T11:46:54Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.issn | 2162-3279 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62630 | - |
dc.description.abstract | Objective We investigated the effect of arterial stiffness on the severity of enlarged perivascular spaces (EPVSs) and cerebral microbleeds (CMBs) at different brain locations. Methods A total of 854 stroke patients underwent both brachial-ankle pulse wave velocity (baPWV) measurement and brain MRI. The extent of EPVS was separately rated at the levels of the basal ganglia (BG) and centrum semiovale (CS). The CMBs were categorized as strictly lobar CMB and deep CMB. The patients were categorized according to baPWV quartiles, and multivariable logistic regressions were performed to evaluate whether the baPWV increment was independently associated with each cerebral SVD marker at different locations. The odds ratio (OR) with 95% confidence interval (CI) was derived on the reference of the first quartile. Results Severe EPVSs at BG and CS were detected in 243 (28.5%) and 353 patients (41.3%), respectively. The increment of baPWV quartiles was associated with both severe BG EPVS burden (Q4: OR = 2.58, CI = 1.45-4.60) and severe CS EPVS burden (Q4: OR = 2.06, CI = 1.24-3.42). Deep CMBs were found in 259 patients (30.3%), and strictly lobar CMBs were found in 170 patients (19.9%). Multivariable logistic regression model revealed deep CMB was independently associated with the baPWV increment (Q4: OR = 2.52, CI = 1.62-3.94). However, strictly lobar CMB had a neutral relationship with baPWV. Conclusion Increased arterial stiffness is consistently associated with the presence of deep CMB and severe EPVS burden at the BG and CS, suggesting a common pathophysiologic mechanism. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Association between arterial stiffness and the presence of cerebral small vessel disease markers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/brb3.1935 | - |
dc.identifier.bibliographicCitation | BRAIN AND BEHAVIOR, v.11, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000590322100001 | - |
dc.identifier.scopusid | 2-s2.0-85096637877 | - |
dc.citation.number | 1 | - |
dc.citation.title | BRAIN AND BEHAVIOR | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | arterial stiffness | - |
dc.subject.keywordAuthor | enlarged perivascular space | - |
dc.subject.keywordAuthor | pulse wave velocity | - |
dc.subject.keywordAuthor | small vessel disease | - |
dc.subject.keywordPlus | ENLARGED PERIVASCULAR SPACES | - |
dc.subject.keywordPlus | LACUNAR STROKE ASSOCIATION | - |
dc.subject.keywordPlus | PULSE-WAVE VELOCITY | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | BASAL GANGLIA | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | BURDEN | - |
dc.subject.keywordPlus | AGE | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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