Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Lee, Hojung | - |
dc.contributor.author | Kim, Eun Kyung | - |
dc.contributor.author | Lee, Won Mi | - |
dc.contributor.author | Hong, Young Ok | - |
dc.contributor.author | Hong, Soon Auck | - |
dc.date.accessioned | 2023-03-08T11:53:32Z | - |
dc.date.available | 2023-03-08T11:53:32Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1541-2016 | - |
dc.identifier.issn | 1533-4058 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/62736 | - |
dc.description.abstract | Programmed cell death 4 (PDCD4) is a tumor suppressor gene that inhibits tumor progression, invasion, and metastasis. Decreased PDCD4 expression is associated with poor prognosis in various types of cancers. We evaluated PDCD4 expression and its clinicopathologic correlation, including patient survival, in 289 surgically resected colorectal cancers. Low nuclear PDCD4 expression was identified in 177 (61.2%) cases and was associated with large tumor size, high pT classification, and the presence of lymphovascular and perineural invasion. The 5-year survival rate of patients with low nuclear PDCD4 expression was significantly lower than that of patients with high expression (72.2% vs. 93.3%, P<0.001). American Joint Committee on Cancer stage II and III colorectal cancer patients with low nuclear PDCD4 expression (76.9% and 67.2%, respectively) showed significantly worse overall survival than those with high expression (100% and 92.9%, P=0.002 and 0.032, respectively). Low nuclear PDCD4 expression was an independent poor prognostic factor in colorectal cancer patients (hazard ratio=3.556; 95% confidence interval, 1.739-7.271; P=0.001). Our study suggests that low PDCD4 expression is associated with aggressive behavior and can be used as a prognostic indicator of colorectal cancer patients. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma | - |
dc.type | Article | - |
dc.identifier.doi | 10.1097/PAI.0000000000000948 | - |
dc.identifier.bibliographicCitation | Applied immunohistochemistry & molecular morphology : AIMM, v.29, no.9, pp 685 - 692 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001071538600009 | - |
dc.identifier.scopusid | 2-s2.0-85118283458 | - |
dc.citation.endPage | 692 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 685 | - |
dc.citation.title | Applied immunohistochemistry & molecular morphology : AIMM | - |
dc.citation.volume | 29 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | colorectal cancers | - |
dc.subject.keywordAuthor | PDCD4 | - |
dc.subject.keywordAuthor | expression | - |
dc.subject.keywordAuthor | prognosis | - |
dc.relation.journalResearchArea | Anatomy & Morphology | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Anatomy & Morphology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.