Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults
DC Field | Value | Language |
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dc.contributor.author | Lee, Jee-Yon | - |
dc.contributor.author | Kim, Jung-Ha | - |
dc.contributor.author | Lee, Duk-Chul | - |
dc.date.available | 2019-03-08T11:57:38Z | - |
dc.date.issued | 2017-11-01 | - |
dc.identifier.issn | 1420-8008 | - |
dc.identifier.issn | 1421-9824 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6286 | - |
dc.description.abstract | Background: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. Methods: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. Results: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). Conclusion: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults. (C) 2017 S. Karger AG, Basel | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults | - |
dc.type | Article | - |
dc.identifier.doi | 10.1159/000480427 | - |
dc.identifier.bibliographicCitation | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v.44, no.3-4, pp 232 - 243 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000414426500012 | - |
dc.identifier.scopusid | 2-s2.0-85030678491 | - |
dc.citation.endPage | 243 | - |
dc.citation.number | 3-4 | - |
dc.citation.startPage | 232 | - |
dc.citation.title | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | - |
dc.citation.volume | 44 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | Telomere length | - |
dc.subject.keywordAuthor | Cognitive decline | - |
dc.subject.keywordAuthor | Mitochondrial DNA copy number | - |
dc.subject.keywordAuthor | Very old adults | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | SYDNEY MEMORY | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | IMPAIRMENT | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordPlus | SHORTER | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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