Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyoung Woo | - |
dc.contributor.author | Ryu, Jin Suk | - |
dc.contributor.author | Kim, Jun Yeob | - |
dc.contributor.author | Kim, Mee Kum | - |
dc.date.accessioned | 2023-03-08T14:03:48Z | - |
dc.date.available | 2023-03-08T14:03:48Z | - |
dc.date.issued | 2020-06 | - |
dc.identifier.issn | 2164-2591 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63409 | - |
dc.description.abstract | Purpose: To investigate the effect of preserved corneal lamellar grafting on inflammation and wound healing and to compare its effect with that of preserved scleral grafting in a scleral defect rabbit model. Methods: New Zealand White rabbits were assigned to a corneal lamellar grafting group (n = 5) or a scleral grafting group (n = 5). After lamellar dissection of superotemporal sclera using 6.0-mm trephine, the same sizes of preserved human corneal or scleral grafts were transplanted with 10-0 nylon interrupted sutures. The grafted areas were photodocumented at 3 to 21 days after surgery to evaluate epithelial wound healing index (%), neovascularization and presence of filaments. The existence of CD3(+) T cells and CD34(+) cells at the grafted areas was analyzed at 21 days. Results: Epithelial wound healing index was significantly higher in the corneal grafting group at 9 days (P<0.05). Scleral grafts showed copious formation of filaments adherent to the engrafted area from 9 to 14 days, whereas the corneal grafts were free of filaments. The numbers of inflammatory cells were significantly higher in the scleral grafts (P < 0.05), and CD3(+) T cells and CD34(+) cells were populated within inflammatory cells at graft-recipient junctions in both groups. The mean areas of the estimated perigraft and intragraft neovascularization tended to be higher in scleral grafts. Conclusions: Preserved corneal lamellar grafting enhances epithelial wound healing and alleviates inflammation in a scleral defect rabbit model. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | - |
dc.title | Preserved Corneal Lamellar Grafting Reduces Inflammation and Promotes Wound Healing in a Scleral Defect Rabbit Model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1167/tvst.9.7.38 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL VISION SCIENCE & TECHNOLOGY, v.9, no.7, pp 1 - 10 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000548221000003 | - |
dc.identifier.scopusid | 2-s2.0-85090642524 | - |
dc.citation.endPage | 10 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | TRANSLATIONAL VISION SCIENCE & TECHNOLOGY | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | preserved cornea | - |
dc.subject.keywordAuthor | lamellar grafting | - |
dc.subject.keywordAuthor | scleromalacia | - |
dc.subject.keywordPlus | EPITHELIAL BASEMENT-MEMBRANE | - |
dc.subject.keywordPlus | AMNIOTIC MEMBRANE | - |
dc.subject.keywordPlus | NECROTIZING SCLERITIS | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | ORGANIZATION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | CD34 | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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