CRISPR Diagnosis and Therapeutics with Single Base Pair Precision
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Seung Hwan | - |
dc.contributor.author | Park, Young-Ho | - |
dc.contributor.author | Jin, Yeung Bae | - |
dc.contributor.author | Kim, Sun-Uk | - |
dc.contributor.author | Hur, Junho K. | - |
dc.date.accessioned | 2023-03-08T14:05:51Z | - |
dc.date.available | 2023-03-08T14:05:51Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1471-4914 | - |
dc.identifier.issn | 1471-499X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63432 | - |
dc.description.abstract | Clustered regularly interspaced short palindromic repeats, or CRISPR, has been widely accepted as a versatile genome editing tool with significant potential for medical application. Reliable allele specificity is one of the most critical elements for successful application of this technology to develop high-precision therapeutics and diagnostics. CRISPR-based genome editing tools achieve high-fidelity distinction of single-base differences in target genomic loci by structural identification of CRISPR-associated (Cas) proteins and sequences of the guide RNAs. In this review, we describe the structural features of ribonucleoprotein complex formation by CRISPR proteins and guide RNAs that eventually recognize target DNA sequences. This structural understanding provides the basis for the recent applications of enhanced single-base precision genome editing technologies for effective distinction of specific alleles. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | CRISPR Diagnosis and Therapeutics with Single Base Pair Precision | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.molmed.2019.09.008 | - |
dc.identifier.bibliographicCitation | TRENDS IN MOLECULAR MEDICINE, v.26, no.3, pp 337 - 350 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000517954900011 | - |
dc.identifier.scopusid | 2-s2.0-85075809901 | - |
dc.citation.endPage | 350 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 337 | - |
dc.citation.title | TRENDS IN MOLECULAR MEDICINE | - |
dc.citation.volume | 26 | - |
dc.type.docType | Review | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | allele specificity | - |
dc.subject.keywordAuthor | CRISPR system | - |
dc.subject.keywordAuthor | diagnosis | - |
dc.subject.keywordAuthor | gene therapy | - |
dc.subject.keywordAuthor | genome editing | - |
dc.subject.keywordPlus | GENOME-WIDE SPECIFICITIES | - |
dc.subject.keywordPlus | RNA-GUIDED ENDONUCLEASE | - |
dc.subject.keywordPlus | R-LOOP COMPLEX | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | HUMAN-CELLS | - |
dc.subject.keywordPlus | DUAL-RNA | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordPlus | CAS9 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.