Preparation and characterization of a lutein loading nanoemulsion system for ophthalmic eye drops
- Authors
- Lim, Chaemin; Kim, Da-won; Sim, Taehoon; Ngoc Ha Hoang; Lee, Jun Won; Lee, Eun Seong; Youn, Yu Seok; Oh, Kyung Teak
- Issue Date
- Dec-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Nanoemulsion; Lutein; Ophthalmic drug delivery system; Emulsion morphology; Pseudo-ternary phase diagram; Nanosize
- Citation
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v.36, pp 168 - 174
- Pages
- 7
- Journal Title
- JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Volume
- 36
- Start Page
- 168
- End Page
- 174
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6392
- DOI
- 10.1016/j.jddst.2016.10.009
- ISSN
- 1773-2247
- Abstract
- Nanoemulsions (NE) are advantageous nanosized delivery agents for ophthalmic medications because of their ability to penetrate into the ocular structure, as well as their sustained effects. We prepared a NE system composed of isopropyl myristate, triacetin, Tween 80, and ethyl alcohol to increase the solubility and permeability of lutein, an effective medication in macular degeneration. The pseudo-ternary phase diagram was constructed to identify the self-emulsifying region. Eight formulations were selected to characterize each formulation. We examined physical characteristics including particle size, drug solubility, formulation stability, and turbidity. We selected the optimized formulations NE 5 (NE-5) and NE-8, both of which are transparent. The particle size of NE was ca. 10-12 nm with a narrow size distribution. Neither separation nor change in the particle size was observed for 7 days. The lutein loading NEs demonstrated a significant increase in lutein release and sustained release. In contrast, lutein prepared with oil and starch had. limited drug release profiles under 5%. The prepared lutein NE formulation is a potential alternative for lutein delivery systems. (C) 2016 Elsevier B.V. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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