Quiescence Exit of Tert(+) Stem Cells by Wnt/beta-Catenin Is Indispensable for Intestinal Regeneration
DC Field | Value | Language |
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dc.contributor.author | Suh, Han Na | - |
dc.contributor.author | Kim, Moon Jong | - |
dc.contributor.author | Jung, Youn-Sang | - |
dc.contributor.author | Lien, Esther M. | - |
dc.contributor.author | Jun, Sohee | - |
dc.contributor.author | Park, Jae-Il | - |
dc.date.accessioned | 2023-03-08T15:59:43Z | - |
dc.date.available | 2023-03-08T15:59:43Z | - |
dc.date.issued | 2017-11 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63953 | - |
dc.description.abstract | Fine control of stem cell maintenance and activation is crucial for tissue homeostasis and regeneration. However, the mechanism of quiescence exit of Tert(+) intestinal stem cells (ISCs) remains unknown. Employing a Tert knockin (Tert(TCE/+)) mouse model, we found that Tert(+) cells are long-term label-retaining self-renewing cells, which are partially distinguished from the previously identified +4 ISCs. Tert(+) cells become mitotic upon irradiation (IR) injury. Conditional ablation of Tert(+) cells impairs IR-induced intestinal regeneration but not intestinal homeostasis. Upon IR injury, Wnt signaling is specifically activated in Tert(+) cells via the ROS-HIFs-transactivated Wnt2b signaling axis. Importantly, conditional knockout of beta-catenin/Ctnnb1 in Tert(+) cells undermines IR-induced quiescence exit of Tert(+) cells, which subsequently impedes intestinal regeneration. Our results that Wnt-signaling-induced activation of Tert(+) ISCs is indispensable for intestinal regeneration unveil the underlying mechanism for how Tert(+) stem cells undergo quiescence exit upon tissue injury. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CELL PRESS | - |
dc.title | Quiescence Exit of Tert(+) Stem Cells by Wnt/beta-Catenin Is Indispensable for Intestinal Regeneration | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.celrep.2017.10.118 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.21, no.9, pp 2571 - 2584 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000416979500020 | - |
dc.identifier.scopusid | 2-s2.0-85035748976 | - |
dc.citation.endPage | 2584 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2571 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 21 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | intestinal regeneration | - |
dc.subject.keywordAuthor | intestinal stem cells | - |
dc.subject.keywordAuthor | radiation | - |
dc.subject.keywordAuthor | ROS-HIFs-Wnt2b | - |
dc.subject.keywordAuthor | Tert | - |
dc.subject.keywordAuthor | Wnt/β-catenin | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | LGR5 | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | TELOMERASE | - |
dc.subject.keywordPlus | LIVE | - |
dc.subject.keywordPlus | POPULATIONS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PLASTICITY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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