Sustained diffusion reversal with in-bore reperfusion in monkey stroke models: Confirmed by prospective magnetic resonance imaging
DC Field | Value | Language |
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dc.contributor.author | Yi, Kyung Sik | - |
dc.contributor.author | Choi, Chi-Hoon | - |
dc.contributor.author | Lee, Sang-Rae | - |
dc.contributor.author | Lee, Hong Jun | - |
dc.contributor.author | Lee, Youngjeon | - |
dc.contributor.author | Jeong, Kang-Jin | - |
dc.contributor.author | Hwang, Jinwoo | - |
dc.contributor.author | Chang, Kyu-Tae | - |
dc.contributor.author | Cha, Sang-Hoon | - |
dc.date.accessioned | 2023-03-08T16:04:10Z | - |
dc.date.available | 2023-03-08T16:04:10Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0271-678X | - |
dc.identifier.issn | 1559-7016 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/63994 | - |
dc.description.abstract | Although early diffusion lesion reversal after recanalization treatment of acute ischaemic stroke has been observed in clinical settings, the reversibility of lesions observed by diffusion-weighted imaging remains controversial. Here, we present consistent observations of sustained diffusion lesion reversal after transient middle cerebral artery occlusion in a monkey stroke model. Seven rhesus macaques were subjected to endovascular transient middle cerebral artery occlusion with in-bore reperfusion confirmed by repeated prospective diffusion-weighted imaging. Early diffusion lesion reversal was defined as lesion reversal at 3h after reperfusion. Sustained diffusion lesion reversal was defined as the difference between the ADC-derived pre-reperfusion maximal ischemic lesion volume (ADC(D-P Match)) and the lesion on 4-week follow-up FLAIR magnetic resonance imaging. Diffusion lesions were spatiotemporally assessed using a 3-D voxel-based quantitative technique. The ADC(D-P Match) was 9.7 +/- 6.0% (mean +/- SD) and the final infarct was 1.2-6.0% of the volume of the ipsilateral hemisphere. Early diffusion lesion reversal and sustained diffusion lesion reversal were observed in all seven animals, and the calculated percentages compared with their ADC(D-P Match) ranged from 8.3 to 51.9% (mean +/- SD, 26.9 +/- 15.3%) and 41.7-77.8% (mean +/- SD, 65.4 +/- 12.2%), respectively. Substantial sustained diffusion lesion reversal and early reversal were observed in all animals in this monkey model of transient focal cerebral ischaemia. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE PUBLICATIONS INC | - |
dc.title | Sustained diffusion reversal with in-bore reperfusion in monkey stroke models: Confirmed by prospective magnetic resonance imaging | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/0271678X16659302 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, v.37, no.6, pp 2002 - 2012 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000402005200008 | - |
dc.identifier.scopusid | 2-s2.0-85019762512 | - |
dc.citation.endPage | 2012 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2002 | - |
dc.citation.title | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | - |
dc.citation.volume | 37 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Animal model | - |
dc.subject.keywordAuthor | brain ischaemia | - |
dc.subject.keywordAuthor | brain imaging | - |
dc.subject.keywordAuthor | brain recovery | - |
dc.subject.keywordAuthor | diffusion-weighted magnetic resonance imaging | - |
dc.subject.keywordPlus | FOCAL CEREBRAL-ISCHEMIA | - |
dc.subject.keywordPlus | LESION REVERSAL | - |
dc.subject.keywordPlus | PREDICTING TISSUE | - |
dc.subject.keywordPlus | INFARCT GROWTH | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | PERFUSION | - |
dc.subject.keywordPlus | THROMBOLYSIS | - |
dc.subject.keywordPlus | PENUMBRA | - |
dc.subject.keywordPlus | MRI | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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