Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission
DC Field | Value | Language |
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dc.contributor.author | Park, Junghyung | - |
dc.contributor.author | Min, Ju-Sik | - |
dc.contributor.author | Chae, Abcl Unbin | - |
dc.contributor.author | Lee, Joon Yeop | - |
dc.contributor.author | Song, Kyung-Sik | - |
dc.contributor.author | Lee, Hyun-Shik | - |
dc.contributor.author | Lee, Hong Jun | - |
dc.contributor.author | Lee, Sang-Rae | - |
dc.contributor.author | Lee, Dong-Seok | - |
dc.date.accessioned | 2023-03-08T16:07:24Z | - |
dc.date.available | 2023-03-08T16:07:24Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.issn | 1872-8421 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64022 | - |
dc.description.abstract | Oleuropein is a primary phenolic compound found in olive leaf and Fraxinus rhynchophylla. Here, we investigated the impact of oleuropein on LPS-induced BV-2 microglial cells. Oleuropein suppressed the LPS-induced increase in pro-inflammatory mediators, such as nitric oxide, and pro-inflammatory cytokines, via inhibition of ERK/p38/NF-kappa B activation and reactive oxygen species (ROS) generation. Furthermore, it suppressed LPS-induced excessive mitochondrial fission, which regulates mitochondrial ROS generation and pro-inflammatory response by diminishing Drp1 dephosphorylation. Collectively, we demonstrated that oleuropein suppresses pro inflammatory response of microglia by inhibiting Drp1-dependent mitochondrial fission. Our findings suggest a potential role of oleuropein in microglial inflammation-mediated neurodegenerative disorders. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Anti-inflammatory effect of oleuropein on microglia through regulation of Drp1-dependent mitochondrial fission | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jneuroim.2017.02.019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEUROIMMUNOLOGY, v.306, pp 46 - 52 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000400037400008 | - |
dc.identifier.scopusid | 2-s2.0-85015400482 | - |
dc.citation.endPage | 52 | - |
dc.citation.startPage | 46 | - |
dc.citation.title | JOURNAL OF NEUROIMMUNOLOGY | - |
dc.citation.volume | 306 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Oleuropein | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Mitochondrial dynamics | - |
dc.subject.keywordAuthor | Drp1 | - |
dc.subject.keywordAuthor | ROS | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | OLIVE LEAF EXTRACT | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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