Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Diaz, Miguel F. | - |
dc.contributor.author | Vaidya, Abishek B. | - |
dc.contributor.author | Evans, Siobahn M. | - |
dc.contributor.author | Lee, Hyun Jung | - |
dc.contributor.author | Aertker, Benjamin M. | - |
dc.contributor.author | Alexander, Alexander J. | - |
dc.contributor.author | Price, Katherine M. | - |
dc.contributor.author | Ozuna, Joyce A. | - |
dc.contributor.author | Liao, George P. | - |
dc.contributor.author | Aroom, Kevin R. | - |
dc.contributor.author | Xue, Hasen | - |
dc.contributor.author | Gu, Liang | - |
dc.contributor.author | Omichi, Rui | - |
dc.contributor.author | Bedi, Supinder | - |
dc.contributor.author | Olson, Scott D. | - |
dc.contributor.author | Cox, Charles S. | - |
dc.contributor.author | Wenzel, Pamela L. | - |
dc.date.accessioned | 2023-03-08T16:07:32Z | - |
dc.date.available | 2023-03-08T16:07:32Z | - |
dc.date.issued | 2017-05 | - |
dc.identifier.issn | 1066-5099 | - |
dc.identifier.issn | 1549-4918 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64023 | - |
dc.description.abstract | Mesenchymal stromal cells (MSCs) are believed to mobilize from the bone marrow in response to inflammation and injury, yet the effects of egress into the vasculature on MSC function are largely unknown. Here we show that wall shear stress (WSS) typical of fluid frictional forces present on the vascular lumen stimulates antioxidant and anti-inflammatory mediators, as well as chemokines capable of immune cell recruitment. WSS specifically promotes signaling through NFB-COX2-prostaglandin E-2 (PGE(2)) to suppress tumor necrosis factor- (TNF-) production by activated immune cells. Ex vivo conditioning of MSCs by WSS improved therapeutic efficacy in a rat model of traumatic brain injury, as evidenced by decreased apoptotic and M1-type activated microglia in the hippocampus. These results demonstrate that force provides critical cues to MSCs residing at the vascular interface which influence immunomodulatory and paracrine activity, and suggest the potential therapeutic use of force for MSC functional enhancement. Stem Cells2017;35:1259-1272 | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Biomechanical Forces Promote Immune Regulatory Function of Bone Marrow Mesenchymal Stromal Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/stem.2587 | - |
dc.identifier.bibliographicCitation | STEM CELLS, v.35, no.5, pp 1259 - 1272 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000400017200013 | - |
dc.identifier.scopusid | 2-s2.0-85014438532 | - |
dc.citation.endPage | 1272 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1259 | - |
dc.citation.title | STEM CELLS | - |
dc.citation.volume | 35 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Biomechanical force | - |
dc.subject.keywordAuthor | Mesenchymal stromal cells | - |
dc.subject.keywordAuthor | Immunomodulation | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Shear stress | - |
dc.subject.keywordAuthor | Traumatic brain injury | - |
dc.subject.keywordPlus | FLUID SHEAR-STRESS | - |
dc.subject.keywordPlus | ACTIVATED MICROGLIAL/MACROPHAGE RESPONSE | - |
dc.subject.keywordPlus | TRAUMATIC BRAIN-INJURY | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BLOOD-FLOW | - |
dc.subject.keywordPlus | INTERLEUKIN-10 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.