Effect of Oral Administration of 3,3'-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice
DC Field | Value | Language |
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dc.contributor.author | Jeon, Eun-Joo | - |
dc.contributor.author | Davaatseren, Munkhtugs | - |
dc.contributor.author | Hwang, Jin-Taek | - |
dc.contributor.author | Park, Jae Ho | - |
dc.contributor.author | Hur, Haeng Jeon | - |
dc.contributor.author | Lee, Ae Sin | - |
dc.contributor.author | Sung, Mi Jeong | - |
dc.date.accessioned | 2023-03-08T16:52:00Z | - |
dc.date.available | 2023-03-08T16:52:00Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.issn | 1520-5118 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64150 | - |
dc.description.abstract | In patients with inflammatory bowel disease (IBD), inflammation is induced and maintained by lymphangiogenesis, and angiogenesis. 3,3'-Diindolylmethane (DIM) is a natural product formed in acidic conditions from indole-3-carbinol in cruciferous vegetables, and it is known for its chemotherapeutic activity. This study evaluated DIM's effects on angiogenesis, lymphangiogenesis, and inflammation in a mouse colitis model. Experimental colitis was induced in mice by administering 3% dextran sulfate sodium (DSS) via drinking water. DIM remarkably attenuated the clinical signs and histological characteristics in mice with DSS-induced colitis. DIM suppressed neutrophil infiltration and pro-inflammatory cytokines. Moreover, it significantly suppressed the expression of vascular endothelial growth factor (VEGF)-A and VEGF receptor (VEGFR)-2, indicating that the mechanism may be related to the repression of pro-angiogenesis activity. DIM also remarkably suppressed the expression of VEGF-C, VEGF-D, VEGFR-3, and angiopoietin-2; thus, the mechanism may also be related to the suppression of lymphangiogenesis. Therefore, DIM is a possible treatment option for inflammation of the intestine and associated angiogenesis and lymphangiogenesis | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Effect of Oral Administration of 3,3'-Diindolylmethane on Dextran Sodium Sulfate-Induced Acute Colitis in Mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.jafc.6b02604 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.64, no.41, pp 7702 - 7709 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000385991900005 | - |
dc.identifier.scopusid | 2-s2.0-84992130090 | - |
dc.citation.endPage | 7709 | - |
dc.citation.number | 41 | - |
dc.citation.startPage | 7702 | - |
dc.citation.title | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | 3,3'-diindolylmethane | - |
dc.subject.keywordAuthor | inflammatory bowel disease | - |
dc.subject.keywordAuthor | dextran sodium sulfate | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | lymphangiogenesis | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR-3 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ANGIOPOIETIN-2 | - |
dc.subject.keywordPlus | LYMPHATICS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.relation.journalResearchArea | Agriculture | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Agriculture, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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