Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies
DC Field | Value | Language |
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dc.contributor.author | Lee, Woo Kyung | - |
dc.contributor.author | Kim, Ha Yeon | - |
dc.contributor.author | Lee, Jinae | - |
dc.contributor.author | Koh, Shin Ok | - |
dc.contributor.author | Kim, Jeong Min | - |
dc.contributor.author | Na, Sungwon | - |
dc.date.accessioned | 2023-03-08T16:53:34Z | - |
dc.date.available | 2023-03-08T16:53:34Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.issn | 1976-2437 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64168 | - |
dc.description.abstract | Purpose: Owing to the recommendations of the Surviving Sepsis Campaign guidelines, protocol-based resuscitation or goal-directed therapy (GDT) is broadly advocated for the treatment of septic shock. However, the most recently published trials showed no survival benefit from protocol-based resuscitation in septic shock patients. Hence, we aimed to assess the effect of GDT on clinical outcomes in such patients. Materials and Methods: We performed a systematic review that included a meta-analysis. We used electronic search engines including PubMed, Embase, and the Cochrane database to find studies comparing protocol-based GDT to common or standard care in patients with septic shock and severe sepsis. Results: A total of 13269 septic shock patients in 24 studies were included [12 randomized controlled trials (RCTs) and 12 observational studies]. The overall mortality odds ratio (OR) [95% confidence interval (CI)] for GDT versus conventional care was 0.746 (0.631-0.883). In RCTs only, the mortality OR (95% CI) for GDT versus conventional care in the meta-analysis was 0.93 (0.75-1.16). The beneficial effect of GDT decreased as more recent studies were added in an alternative, cumulative meta-analysis. No significant publication bias was found. Conclusion: The result of this meta-analysis suggests that GDT reduces mortality in patients with severe sepsis or septic shock. However, our cumulative meta-analysis revealed that the reduction of mortality risk was diminished as more recent studies were added. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.title | Protocol-Based Resuscitation for Septic Shock: A Meta-Analysis of Randomized Trials and Observational Studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.3349/ymj.2016.57.5.1260 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.57, no.5, pp 1260 - 1270 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000388218800028 | - |
dc.identifier.scopusid | 2-s2.0-84978044431 | - |
dc.citation.endPage | 1270 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1260 | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 57 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Sepsis | - |
dc.subject.keywordAuthor | septic shock | - |
dc.subject.keywordAuthor | shock | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordPlus | GOAL-DIRECTED THERAPY | - |
dc.subject.keywordPlus | MAXIMIZING OXYGEN DELIVERY | - |
dc.subject.keywordPlus | SEPSIS CAMPAIGN GUIDELINES | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordPlus | IMPLEMENTATION | - |
dc.subject.keywordPlus | ELEVATION | - |
dc.subject.keywordPlus | BUNDLE | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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