Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of 2 Multicenter Prospective Studies
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyoung Jin | - |
dc.contributor.author | Hong, Kyung Taek | - |
dc.contributor.author | Lee, Ji Won | - |
dc.contributor.author | Kim, Hyery | - |
dc.contributor.author | Park, Kyung Duk | - |
dc.contributor.author | Shin, Hee Young | - |
dc.contributor.author | Lee, Soo Hyun | - |
dc.contributor.author | Yoo, Keon Hee | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.contributor.author | Lee, Jae Wook | - |
dc.contributor.author | Chung, Nak Gyun | - |
dc.contributor.author | Cho, Bin | - |
dc.contributor.author | Kim, Hack Ki | - |
dc.contributor.author | Koh, Kyung Nam | - |
dc.contributor.author | Im, Ho Joon | - |
dc.contributor.author | Seo, Jong Jin | - |
dc.contributor.author | Jung, Hyun Joo | - |
dc.contributor.author | Park, Jun Eun | - |
dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Lim, Young Tak | - |
dc.contributor.author | Lim, Yeon Jung | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Yoo, Eun Sun | - |
dc.contributor.author | Ryu, Kyung Ha | - |
dc.contributor.author | Lee, Jae Hee | - |
dc.contributor.author | Park, Jeong-A | - |
dc.contributor.author | Park, Sang Kyu | - |
dc.contributor.author | Ahn, Hyo Seop | - |
dc.date.accessioned | 2023-03-08T16:59:19Z | - |
dc.date.available | 2023-03-08T16:59:19Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 1083-8791 | - |
dc.identifier.issn | 1523-6536 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64189 | - |
dc.description.abstract | Hematopoietic stem cell transplantation (HSCT) is a curative therapy for severe aplastic anemia (SAA); however, the optimal conditioning regimen for HSCT with an unrelated donor has not yet been defined. A previous study using a fludarabine (FLU), cyclophosphamide (Cy), and antithymocyte globulin (ATG) conditioning regimen (study A: 50 mg/kg Cy once daily i.v. on days -9, -8, -7, and -6; 30 mg/m(2) FLU once daily i.v. on days -5, -4, -3, and -2; and 2.5 mg/kg of ATG once daily i.v. on days -3, -2, and -1) demonstrated successful engraftment (100%) but had a high treatment-related mortality rate (32.1%). Therefore, given that Cy is more toxic than FLU, we performed a new phase II prospective study with a reduced-toxicity regimen (study B: 60 mg/kg Cy once daily i.v. on days -8 and -7; 40 mg/m(2) FLU once daily i.v. on days -6, -5, -4, -3, and -2; and 2.5 mg/kg ATG once daily i.v. on 3 days). Fifty-seven patients were enrolled in studies A (n = 28) and B (n = 29), and donor type hematologic recovery was achieved in all patients in both studies. The overall survival (OS) and event-free survival (EFS) rates of patients in study B was markedly improved compared with those in study A (OS: 96.7% versus 67.9%, respectively, P =.004; EFS: 93.3% versus 64.3%, respectively, P =.008). These data show that a reduced-toxicity conditioning regimen with FLU, Cy, and ATG may be an optimal regimen for SAA patients receiving unrelated donor HSCT. (C) 2016 American Society for Blood and Marrow Transplantation. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Improved Outcome of a Reduced Toxicity-Fludarabine, Cyclophosphamide, plus Antithymocyte Globulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of 2 Multicenter Prospective Studies | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbmt.2016.04.003 | - |
dc.identifier.bibliographicCitation | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.22, no.8, pp 1455 - 1459 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000380417400017 | - |
dc.identifier.scopusid | 2-s2.0-84976516781 | - |
dc.citation.endPage | 1459 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1455 | - |
dc.citation.title | BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Severe aplastic anemia | - |
dc.subject.keywordAuthor | Unrelated donor | - |
dc.subject.keywordAuthor | Fludarabine | - |
dc.subject.keywordAuthor | Cyclophosphamide | - |
dc.subject.keywordAuthor | Thymoglobulin | - |
dc.subject.keywordAuthor | Antithymocyte globulin (ATG) | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | MARROW TRANSPLANTATION | - |
dc.subject.keywordPlus | IMMUNOSUPPRESSIVE THERAPY | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | FAILURE | - |
dc.subject.keywordPlus | THYMOGLOBULIN | - |
dc.subject.keywordPlus | IRRADIATION | - |
dc.subject.keywordPlus | ATG | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Transplantation | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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