High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Children with High-Risk or Recurrent Bone and Soft Tissue Sarcomas
DC Field | Value | Language |
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dc.contributor.author | Choi, Young Bae | - |
dc.contributor.author | Yi, Eun Sang | - |
dc.contributor.author | Lee, Ji Won | - |
dc.contributor.author | Yoo, Keon Hee | - |
dc.contributor.author | Sung, Ki Woong | - |
dc.contributor.author | Koo, Hong Hoe | - |
dc.date.accessioned | 2023-03-08T17:05:06Z | - |
dc.date.available | 2023-03-08T17:05:06Z | - |
dc.date.issued | 2016-07 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.issn | 1598-6357 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64207 | - |
dc.description.abstract | Despite increasing evidence that high-dose chemotherapy and autologous stem cell transplantation (HDCT/auto-SCT) might improve the survival of patients with high-risk or recurrent solid tumors, therapy effectiveness for bone and soft tissue sarcoma treatment remains unclear. This study retrospectively investigated the feasibility and effectiveness of HDCT/auto-SCT for high-risk or recurrent bone and soft tissue sarcoma. A total of 28 patients (18 high-risk and 10 recurrent) underwent single or tandem HDCT/auto-SCT between October 2004 and September 2014. During follow-up of a median 15.3 months, 18 patients exhibited disease progression and 2 died of treatment-related toxicities (1 veno-occlusive disease and 1 sepsis). Overall, 8 patients remained alive and progression-free. The 3-year overall survival (OS) and event-free survival (EFS) rates for all 28 patients were 28.7% and 26.3%, respectively. In the subgroup analysis, OS and EFS rates were higher in patients with complete or partial remission prior to HDCT/auto-SCT than in those with worse responses (OS, 39.1% vs. 0.0%, P=0.002; EFS, 36.8% vs. 0.0%, P < 0.001). Therefore, careful selection of patients who can benefit from HDCT/auto-SCT and maximal effort to reduce tumor burden prior to treatment will be important to achieve favorable outcomes in patients with high-risk or recurrent bone and soft tissue sarcomas. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Children with High-Risk or Recurrent Bone and Soft Tissue Sarcomas | - |
dc.type | Article | - |
dc.identifier.doi | 10.3346/jkms.2016.31.7.1055 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.31, no.7, pp 1055 - 1062 | - |
dc.identifier.kciid | ART002113636 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000377169700009 | - |
dc.identifier.scopusid | 2-s2.0-85047289502 | - |
dc.citation.endPage | 1062 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1055 | - |
dc.citation.title | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.citation.volume | 31 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Bone and Soft Tissue Sarcoma | - |
dc.subject.keywordAuthor | Children | - |
dc.subject.keywordAuthor | High-Dose Chemotherapy | - |
dc.subject.keywordAuthor | Autologous Stem Cell Transplantation | - |
dc.subject.keywordPlus | PRIMITIVE NEUROECTODERMAL TUMOR | - |
dc.subject.keywordPlus | EWING FAMILY TUMORS | - |
dc.subject.keywordPlus | INTENSIVE CHEMOTHERAPY | - |
dc.subject.keywordPlus | CONSOLIDATION THERAPY | - |
dc.subject.keywordPlus | ONCOLOGY-GROUP | - |
dc.subject.keywordPlus | NEUROBLASTOMA | - |
dc.subject.keywordPlus | RESCUE | - |
dc.subject.keywordPlus | ETOPOSIDE | - |
dc.subject.keywordPlus | RHABDOMYOSARCOMA | - |
dc.subject.keywordPlus | MELPHALAN | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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