Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study
DC Field | Value | Language |
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dc.contributor.author | Youn, Hae Jeong | - |
dc.contributor.author | Kim, Soo Young | - |
dc.contributor.author | Park, Minji | - |
dc.contributor.author | Jung, Won Hee | - |
dc.contributor.author | Lee, Yang Won | - |
dc.contributor.author | Choe, Yong Beom | - |
dc.contributor.author | Ahn, Kyu Joong | - |
dc.date.available | 2019-03-08T11:59:54Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.issn | 2005-3894 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6430 | - |
dc.description.abstract | Background: Seborrheic dermatitis (SD) is a multifactorial disease; Ma/assezia species play an important role in its pathogenesis. Objective: We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms. Methods: We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. The casual sebum level (measured with Sebumeter((R)); Courage & Khazaka Electronic GmbH, Germany) and the extent of erythema (measured with Mexameter((R)); Courage & Khazaka Electronic GmbH) on the face were measured at baseline and after 4 weeks. The minimal inhibitory concentration (MIC) was determined to demonstrate the antifungal activity of the C/P cream. Results: The casual sebum level and erythema were measured at week 4, and the median values demonstrated a quantitative improvement on the C/P cream-treated right side of the face compared to the emollient cream-treated left side. For the C/P cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricts, M. globosa, M. sympodia/is, and M. slooffiae, respectively. Conclusion: Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | - |
dc.title | Efficacy and Safety of Cream Containing Climbazole/Piroctone Olamine for Facial Seborrheic Dermatitis: A Single-Center, Open-Label Split-Face Clinical Study | - |
dc.type | Article | - |
dc.identifier.doi | 10.5021/ad.2016.28.6.733 | - |
dc.identifier.bibliographicCitation | ANNALS OF DERMATOLOGY, v.28, no.6, pp 733 - 739 | - |
dc.identifier.kciid | ART002170002 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000397356100009 | - |
dc.identifier.scopusid | 2-s2.0-85000733361 | - |
dc.citation.endPage | 739 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 733 | - |
dc.citation.title | ANNALS OF DERMATOLOGY | - |
dc.citation.volume | 28 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Climbazole | - |
dc.subject.keywordAuthor | Malassezia species | - |
dc.subject.keywordAuthor | Piroctone olamine | - |
dc.subject.keywordAuthor | Seborrheic dermatitis | - |
dc.subject.keywordPlus | MALASSEZIA-FURFUR | - |
dc.subject.keywordPlus | SCALP | - |
dc.subject.keywordPlus | DANDRUFF | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | INDIVIDUALS | - |
dc.subject.keywordPlus | ETIOLOGY | - |
dc.subject.keywordPlus | MODERATE | - |
dc.subject.keywordPlus | INVITRO | - |
dc.subject.keywordPlus | DENSITY | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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