Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design
DC Field | Value | Language |
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dc.contributor.author | Jun, Yun Ju | - |
dc.contributor.author | Lee, Jinhee | - |
dc.contributor.author | Hwang, Sehee | - |
dc.contributor.author | Kwak, Jung Hyun | - |
dc.contributor.author | Ahn, Hyeon Yeong | - |
dc.contributor.author | Bak, Youn Kyung | - |
dc.contributor.author | Koh, Jihoon | - |
dc.contributor.author | Lee, Jong Ho | - |
dc.date.accessioned | 2023-03-08T17:53:14Z | - |
dc.date.available | 2023-03-08T17:53:14Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 1745-6215 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64320 | - |
dc.description.abstract | Background: Previous studies have reported that xylose selectively inhibited the activity of sucrase. Xylose supplementation may have a beneficial effect on the postprandial glycemic response. However, no studies have investigated patients with IFG or the effectivity of a dose of D-xylose less than 10 % (w/w). Methods: The present study determined the effect of xylose consumption on postprandial hyperglycemia in normal (n = 25) and hyperglycemic subjects (n = 50). Subjects in this double-blind crossover design study were randomly assigned to consume a sucrose drink (Control, sucrose 50 g + deionized water 100 g) or a sucrose drink additionally containing 5 g (Test 1, sucrose: xylose = 10:1), 3.33 g (Test 2, sucrose: xylose = 15:1), or 2.5 g (Test 3, sucrose: xylose = 20:1) of D-xylose separated by a one-week interval. Results: Normal subjects in all test groups exhibited a significant decrease in serum glucose levels 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. Significantly lower serum levels of insulin were observed at 15 min and 30 min after consuming the xylose-containing drinks compared to the control group. The test 1 group also exhibited a significantly lower insulin area under the curve than the control group. Hyperglycemic subjects (n = 50) in all test groups exhibited a significant decrease in serum glucose levels at 30 min compared to the control group. However, the test 1 group exhibited a significant increase in serum glucose levels at 120 min compared to the control group. Glucose-related markers did not significantly differ in each group. Conclusion: Xylose supplementation may exert a beneficial effect on postprandial glycemic responses in subjects with normal glucose levels and prediabetes. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Beneficial effect of xylose consumption on postprandial hyperglycemia in Korean: a randomized double-blind, crossover design | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13063-016-1261-0 | - |
dc.identifier.bibliographicCitation | TRIALS, v.17, no.1 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000371967500002 | - |
dc.identifier.scopusid | 2-s2.0-85007496872 | - |
dc.citation.number | 1 | - |
dc.citation.title | TRIALS | - |
dc.citation.volume | 17 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Xylose | - |
dc.subject.keywordAuthor | Prediabetes | - |
dc.subject.keywordAuthor | Postprandial hyperglycemia | - |
dc.subject.keywordAuthor | Glucose | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | SUCROSE | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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