Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ryu, Sun | - |
dc.contributor.author | Lee, Seung-Hoon | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.date.accessioned | 2023-03-08T17:54:57Z | - |
dc.date.available | 2023-03-08T17:54:57Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 1673-5374 | - |
dc.identifier.issn | 1876-7958 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64338 | - |
dc.description.abstract | Transplantation of human neural stem cells into the dentate gyrus or ventricle of rodents has been reportedly to enhance neurogenesis. In this study, we examined endogenous stem cell proliferation and angiogenesis in the ischemic rat brain after the transplantation of human neural stem cells. Focal cerebral ischemia in the rat brain was induced by middle cerebral artery occlusion. Human neural stem cells were transplanted into the subventricular zone. The behavioral performance of human neural stem cells-treated ischemic rats was significantly improved and cerebral infarct volumes were reduced compared to those in untreated animals. Numerous transplanted human neural stem cells were alive and preferentially localized to the ipsilateral ischemic hemisphere. Furthermore, 5-bromo-2'-deoxyuridine-labeled endogenous neural stem cells were observed in the subventricular zone and hippocampus, where they differentiated into cells immunoreactive for the neural markers doublecortin, neuronal nuclear antigen NeuN, and astrocyte marker glial fibrillary acidic protein in human neural stem cells-treated rats, but not in the untreated ischemic animals. The number of 5-bromo-2'-deoxyuridine-positive / anti-von Willebrand factor-positive proliferating endothelial cells was higher in the ischemic boundary zone of human neural stem cells-treated rats than in controls. Finally, transplantation of human neural stem cells in the brains of rats with focal cerebral ischemia promoted the proliferation of endogenous neural stem cells and their differentiation into mature neural-like cells, and enhanced angiogenesis. This study provides valuable insights into the effect of human neural stem cell transplantation on focal cerebral ischemia, which can be applied to the development of an effective therapy for stroke. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WOLTERS KLUWER MEDKNOW PUBLICATIONS | - |
dc.title | Human neural stem cells promote proliferation of endogenous neural stem cells and enhance angiogenesis in ischemic rat brain | - |
dc.type | Article | - |
dc.identifier.doi | 10.4103/1673-5374.177739 | - |
dc.identifier.bibliographicCitation | NEURAL REGENERATION RESEARCH, v.11, no.2, pp 298 - 304 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000373221900032 | - |
dc.identifier.scopusid | 2-s2.0-84962574394 | - |
dc.citation.endPage | 304 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 298 | - |
dc.citation.title | NEURAL REGENERATION RESEARCH | - |
dc.citation.volume | 11 | - |
dc.type.docType | Article | - |
dc.publisher.location | 인도 | - |
dc.subject.keywordAuthor | nerve regeneration | - |
dc.subject.keywordAuthor | focal cerebral ischemia | - |
dc.subject.keywordAuthor | middle cerebral artery occlusion | - |
dc.subject.keywordAuthor | human neural stem cells | - |
dc.subject.keywordAuthor | transplantation | - |
dc.subject.keywordAuthor | differentiation | - |
dc.subject.keywordAuthor | infarct size | - |
dc.subject.keywordAuthor | behavioral analysis | - |
dc.subject.keywordAuthor | endogenous neurogenesis | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | rats | - |
dc.subject.keywordAuthor | neural regeneration | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.