Quantitative determination of a synthetic amide derivative of gallic acid, SG-HQ2, using liquid chromatography tandem mass spectrometry, and its pharmacokinetics in rats
DC Field | Value | Language |
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dc.contributor.author | Seo, Seung-Yong | - |
dc.contributor.author | Kang, Wonku | - |
dc.date.available | 2019-03-08T11:59:58Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.issn | 1873-264X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/6433 | - |
dc.description.abstract | An amide derivative of gallic add (GA), 3,4,5-trihydroxy-N-(8-hydroxyquinolin-2-yl)benzamide) (SG-HQ2) was recently synthesized, and its inhibitory actions were previously shown on histamine release and pro-inflammatory cytokine expression. In this study, a simultaneous quantification method was developed for the determination of SG-HQ2 and its possible metabolite, GA, in rat plasma using liquid chromatography with a tandem mass spectrometry (LC-MS/MS). After simple protein precipitation with acetonitrile including diclofenac (internal standard, IS), the analytes were chromatographed on a reversed phased column with a mobile phase of acetonitrile and water (60:40, v/v, including 0.1% formic acid). The ion transitions of the precursor to the product ion were principally protonated ion [M+H](+) at m/z 313.2 -> 160.6 for SG-HQ2, and deprotonated ions [M-H](-) at m/z 168.7 -> 124.9 for GA and 296.0 -> 251.6 for the IS. The accuracy and precision of the assay were in accordance with FDA regulations for the validation of bioanalytical methods. This method was successfully applied to a pharmacokinetic study of SG-HQ2 after intravenous administration in rats. (C) 2016 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Quantitative determination of a synthetic amide derivative of gallic acid, SG-HQ2, using liquid chromatography tandem mass spectrometry, and its pharmacokinetics in rats | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jpba.2016.08.015 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, v.131, pp 103 - 106 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000387628400014 | - |
dc.identifier.scopusid | 2-s2.0-84983522070 | - |
dc.citation.endPage | 106 | - |
dc.citation.startPage | 103 | - |
dc.citation.title | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | - |
dc.citation.volume | 131 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | SG-HQ2 | - |
dc.subject.keywordAuthor | Gallic acid | - |
dc.subject.keywordAuthor | LC-MS/MS | - |
dc.subject.keywordAuthor | Rat | - |
dc.subject.keywordAuthor | Pharmacokinetics | - |
dc.subject.keywordPlus | HISTAMINE-RELEASE | - |
dc.subject.keywordPlus | UHPLC-MS/MS | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordPlus | METABOLITES | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Analytical | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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