Role of autophagy-related protein expression in patients with rectal cancer treated with neoadjuvant chemoradiotherapyopen access
- Authors
- Ko, Y. H.; Sun, D. S.; Won, H. S.; Lee, M. A.; Hong, S. U.; Jung, J. -H.; Cho, H. -M.; Shim, B.
- Issue Date
- Dec-2015
- Publisher
- OXFORD UNIV PRESS
- Citation
- ANNALS OF ONCOLOGY, v.26, no.S9, pp 56 - 56
- Pages
- 1
- Journal Title
- ANNALS OF ONCOLOGY
- Volume
- 26
- Number
- S9
- Start Page
- 56
- End Page
- 56
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64425
- DOI
- 10.1093/annonc/mdv523.46
- ISSN
- 0923-7534
1569-8041
- Abstract
- Aim/Background: Autophagy, a cellular degradation process, has complex roles in tumourigenesis and resistance to cancer treatment in humans. The aim of this study was to explore the expression levels of autophagy-related proteins in patients with rectal cancer and evaluate their clinical role in the neoadjuvant chemoradiotherapy setting.
Methods: All specimens evaluated were obtained from 101 patients with colorectal cancer who had undergone neoadjuvant chemoradiotherapy and curative surgery. The primary outcomes measured were the expression levels of two autophagy-related proteins (microtubule-associated protein 1 light chain 3 beta (LC3b) and beclin-1) by immunohistochemistry and their association with clinicopathological parameters and patient survival.
Results: Among the 101 patients, the frequency of high expression of beclin-1 was 31.7% (32/101) and that of LC3b was 46.5% (47/101). A pathologic complete response was inversely associated with LC3b expression (P = 0.003) and alterations in the expression of autophagy-related proteins (P = 0.046). In the multivariate analysis, however, autophagy-related protein expression did not show prognostic significance for relapse-free survival or overall survival.
Conclusions: High expression of autophagy-related proteins shows a strong negative association with the efficacy of neoadjuvant chemoradiotherapy in patients with rectal cancer. Autophagy has clear implications as a therapeutic target with which to improve the efficacy of neoadjuvant chemoradiotherapy.
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