Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappa B pathways
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nam, Yoon Jeong | - |
dc.contributor.author | Lee, Da Hee | - |
dc.contributor.author | Lee, Min Sung | - |
dc.contributor.author | Lee, Chung Soo | - |
dc.date.accessioned | 2023-03-08T18:35:33Z | - |
dc.date.available | 2023-03-08T18:35:33Z | - |
dc.date.issued | 2015-09 | - |
dc.identifier.issn | 0028-1298 | - |
dc.identifier.issn | 1432-1912 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/64487 | - |
dc.description.abstract | Microbial product lipopolysaccharide has been shown to be involved in the pathogenesis of inflammatory skin diseases. Parthenolide present in extracts of the herb feverfew has demonstrated an anti-inflammatory effect. However, the effect of parthenolide on the Akt/mTOR and NF-kappa B pathway activation-induced productions of inflammatory mediators in keratinocytes has not been studied. Using human keratinocytes, we investigated the effect of parthenolide on the inflammatory mediator production in relation to the Toll-like receptor-4-mediated-Akt/mTOR and NF-kappa B pathways, which regulate the transcription genes involved in immune and inflammatory responses. Parthenolide, Akt inhibitor, Bay 11-7085, and N-acetylcysteine each attenuated the lipopolysaccharide-induced production of IL-1 beta and PGE(2), increase in the levels of cyclooxygenase, formation of reactive oxygen species, increase in the levels of Toll-like receptor-4, and activation of the Akt/mTOR and NF-kappa B in keratinocytes. The results show that parthenolide appears to attenuate the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappa B pathways. The activation of signaling transduction pathways appear to be regulated by reactive oxygen species. Parthenolide appears to attenuate the microbial product-mediated inflammatory skin diseases. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappa B pathways | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00210-015-1132-3 | - |
dc.identifier.bibliographicCitation | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, v.388, no.9, pp 921 - 930 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000359812300002 | - |
dc.identifier.scopusid | 2-s2.0-84939270267 | - |
dc.citation.endPage | 930 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 921 | - |
dc.citation.title | NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | - |
dc.citation.volume | 388 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Keratinocytes | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Parthenolide | - |
dc.subject.keywordAuthor | Toll-like receptor-4 | - |
dc.subject.keywordAuthor | Akt, mTOR, and NF-kappa B pathways | - |
dc.subject.keywordAuthor | Inflammatory mediator production | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | HUMAN KERATINOCYTES | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.